How does baseline anthropometry affect anthropometric outcomes in children receiving treatment for severe acute malnutrition? A secondary analysis of a randomized controlled trial

• Published in: Maternal and child nutrition Vol. 18; no. 3; pp. e13329 - n/a
• Main Authors: Dah, Clarisse, Ourohire, Millogo, Sié, Ali, Ouédraogo, Moussa, Bountogo, Mamadou, Boudo, Valentin, Lebas, Elodie, Nyatigo, Fanice, Arnold, Benjamin F., O'Brien, Kieran S., Oldenburg, Catherine E.
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.07.2022; John Wiley and Sons Inc; Wiley
• Subjects: Anthropometry; Antibiotics; Arm; Body Weight; Care and treatment; Child; Clinical trials; Comparative analysis; Growth Disorders - epidemiology; Humans; Infant; Malnutrition; mid‐upper arm circumference; Mortality; Original; Patient outcomes; screening; severe acute malnutrition; Severe Acute Malnutrition - diagnosis; Severe Acute Malnutrition - epidemiology; Severe Acute Malnutrition - therapy; Thinness; wasting; Weight Gain; weight‐for‐height Z‐score; mid-upper arm circumference; wasting; screening; severe acute malnutrition; weight-for-height Z-score
• ISSN: 1740-8695; 1740-8709
• DOI: 10.1111/mcn.13329

Mid‐upper arm circumference (MUAC) < 11.5 cm and weight‐for‐height Z‐score (WHZ) < −3 are used for screening for severe acute malnutrition (SAM). Underweight and concurrent wasting and stunting may better target those at the highest risk of mortality. We compared anthropometric outcomes in children enrolled in a trial of antibiotics for SAM based on categories of baseline anthropometry, including indicators for programme admission (WHZ < −3, MUAC < 11.5) and alternative indicators (weight‐for‐age Z‐score [WAZ] < −3, concurrent wasting and stunting [WHZ < −3 and height‐for‐age Z‐score < −3]). Participants were followed weekly until nutritional recovery and at 8 weeks. We evaluated changes in weight gain (g/kg/day), MUAC, and WHZ in children admitted by admissions criteria (MUAC only, WHZ only, or MUAC and WHZ) and by underweight or concurrent wasting and stunting. Of 301 admitted children, 100 (33%) were admitted based on MUAC only, 41 (14%) WHZ only, and 160 (53%) both MUAC and WHZ, 210 (68%) were underweight and 67 (22%) were concurrently wasted/stunted. Low MUAC and low WHZ children had the lowest probability of nutritional recovery (17% vs. 50% for MUAC‐only and 34% for WHZ‐only). There was no difference in weight gain velocity or WHZ by admissions criteria (WHZ and/or MUAC). Underweight and concurrently wasted/stunted children had lower MUAC and WHZ at 8 weeks compared with those who were not underweight or concurrently wasted and stunted. Children with both low MUAC and low WHZ had the worst outcomes. Relying on MUAC alone may miss children who have poor outcomes. Other indicators, such as WAZ, may be useful for identifying vulnerable children. Weight‐for‐height Z‐score (WHZ) and mid‐upper arm circumference (MUAC) are used for screening for severe acute malnutrition, but alternative indicators such as weight‐for‐age Z‐score (WAZ) may identify children at high risk of mortality. We evaluated anthropometric outcomes in children with severe acute malnutrition by baseline anthropometric status. Children with both low WHZ and MUAC had the worst outcomes, and low WAZ additionally identified children with poor outcomes Key messages Mid‐upper arm circumference (MUAC) and weight‐for‐height Z‐score (WHZ) are currently used for severe acute malnutrition (SAM) screening, but alternative indicators such as weight‐for‐age Z‐score (WAZ) may be additional options. Children admitted to the nutritional program based on both low MUAC and low WHZ had the worst outcomes, including the lowest probability of nutritional recovery and the worst anthropometric outcomes. While MUAC identified most children with SAM, WHZ may provide additional information about poor outcomes beyond MUAC alone. WAZ may be a useful alternative indicator to identify children who would benefit from a therapeutic feeding program without requiring height measurement.