The Role of Genetics, Epigenetics, and the Environment in ASD: A Mini Review

According to recent findings, variances in autism spectrum disorder (ASD) risk factors might be determined by several factors, including molecular genetic variants. Accumulated evidence has also revealed the important role of biological and chemical pathways in ASD aetiology. In this paper, we asses...

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Published inEpigenomes Vol. 6; no. 2; p. 15
Main Authors Khogeer, Asim A., AboMansour, Iman S., Mohammed, Dia A.
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 19.06.2022
MDPI
Subjects
Analysis
Attention deficit hyperactivity disorder
Autism
autism spectrum disorder
Comorbidity
DNA methylation
Epigenetic inheritance
Epigenetics
Etiology
Families & family life
Gene expression
Genetic aspects
Genetic diversity
Genetic engineering
genetics
Genomes
molecular mechanisms
Mutation
Pervasive developmental disorders
Proteins
rare variants
Review
Risk factors
Siblings
Twins
Saudi Arabia
rare variants
molecular mechanisms
genetics
DNA methylation
autism spectrum disorder
epigenetics
common variants
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Abstract According to recent findings, variances in autism spectrum disorder (ASD) risk factors might be determined by several factors, including molecular genetic variants. Accumulated evidence has also revealed the important role of biological and chemical pathways in ASD aetiology. In this paper, we assess several reviews with regard to their quality of evidence and provide a brief outline of the presumed mechanisms of the genetic, epigenetic, and environmental risk factors of ASD. We also review some of the critical literature, which supports the basis of each factor in the underlying and specific risk patterns of ASD. Finally, we consider some of the implications of recent research regarding potential molecular targets for future investigations.
AbstractList According to recent findings, variances in autism spectrum disorder (ASD) risk factors might be determined by several factors, including molecular genetic variants. Accumulated evidence has also revealed the important role of biological and chemical pathways in ASD aetiology. In this paper, we assess several reviews with regard to their quality of evidence and provide a brief outline of the presumed mechanisms of the genetic, epigenetic, and environmental risk factors of ASD. We also review some of the critical literature, which supports the basis of each factor in the underlying and specific risk patterns of ASD. Finally, we consider some of the implications of recent research regarding potential molecular targets for future investigations.According to recent findings, variances in autism spectrum disorder (ASD) risk factors might be determined by several factors, including molecular genetic variants. Accumulated evidence has also revealed the important role of biological and chemical pathways in ASD aetiology. In this paper, we assess several reviews with regard to their quality of evidence and provide a brief outline of the presumed mechanisms of the genetic, epigenetic, and environmental risk factors of ASD. We also review some of the critical literature, which supports the basis of each factor in the underlying and specific risk patterns of ASD. Finally, we consider some of the implications of recent research regarding potential molecular targets for future investigations.
According to recent findings, variances in autism spectrum disorder (ASD) risk factors might be determined by several factors, including molecular genetic variants. Accumulated evidence has also revealed the important role of biological and chemical pathways in ASD aetiology. In this paper, we assess several reviews with regard to their quality of evidence and provide a brief outline of the presumed mechanisms of the genetic, epigenetic, and environmental risk factors of ASD. We also review some of the critical literature, which supports the basis of each factor in the underlying and specific risk patterns of ASD. Finally, we consider some of the implications of recent research regarding potential molecular targets for future investigations.
Audience Academic
Author Mohammed, Dia A.
AboMansour, Iman S.
Khogeer, Asim A.
AuthorAffiliation 2 Medical Genetics Unit, Maternity & Children Hospital, Makkah Healthcare Cluster, Ministry of Health, Makkah 24382, Saudi Arabia; dimohammed@moh.gov.sa
1 Research Department, The Strategic Planning Administration, General Directorate of Health Affairs of Makkah Region, Ministry of Health, Makkah 24382, Saudi Arabia
3 Scientific Council, Molecular Research and Training Center, iGene, Jeddah 3925, Saudi Arabia
5 Neurogenetic Section, Department of Pediatrics, King Faisal Specialist Hospital and Research Center, Jeddah 2865, Saudi Arabia
4 Department of Medical Genetics, Faculty of Medicine, Umm Al-Qura University, Makkah 24382, Saudi Arabia; isabumansour@uqu.edu.sa
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– name: 3 Scientific Council, Molecular Research and Training Center, iGene, Jeddah 3925, Saudi Arabia
– name: 4 Department of Medical Genetics, Faculty of Medicine, Umm Al-Qura University, Makkah 24382, Saudi Arabia; isabumansour@uqu.edu.sa
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Keywords rare variants
molecular mechanisms
genetics
DNA methylation
autism spectrum disorder
epigenetics
common variants
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Snippet According to recent findings, variances in autism spectrum disorder (ASD) risk factors might be determined by several factors, including molecular genetic...
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SubjectTerms Analysis
Attention deficit hyperactivity disorder
Autism
autism spectrum disorder
Comorbidity
DNA methylation
Epigenetic inheritance
Epigenetics
Etiology
Families & family life
Gene expression
Genetic aspects
Genetic diversity
Genetic engineering
genetics
Genomes
molecular mechanisms
Mutation
Pervasive developmental disorders
Proteins
rare variants
Review
Risk factors
Siblings
Twins
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Title The Role of Genetics, Epigenetics, and the Environment in ASD: A Mini Review
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Volume 6
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