The khmer software package: enabling efficient nucleotide sequence analysis [version 1; peer review: 2 approved, 1 approved with reservations]

• Published in: F1000 research Vol. 4; p. 900
• Main Authors: Crusoe, Michael R, Alameldin, Hussien F, Awad, Sherine, Boucher, Elmar, Caldwell, Adam, Cartwright, Reed, Charbonneau, Amanda, Constantinides, Bede, Edvenson, Greg, Fay, Scott, Fenton, Jacob, Fenzl, Thomas, Fish, Jordan, Garcia-Gutierrez, Leonor, Garland, Phillip, Gluck, Jonathan, González, Iván, Guermond, Sarah, Guo, Jiarong, Gupta, Aditi, Herr, Joshua R, Howe, Adina, Hyer, Alex, Härpfer, Andreas, Irber, Luiz, Kidd, Rhys, Lin, David, Lippi, Justin, Mansour, Tamer, McA'Nulty, Pamela, McDonald, Eric, Mizzi, Jessica, Murray, Kevin D, Nahum, Joshua R, Nanlohy, Kaben, Nederbragt, Alexander Johan, Ortiz-Zuazaga, Humberto, Ory, Jeramia, Pell, Jason, Pepe-Ranney, Charles, Russ, Zachary N, Schwarz, Erich, Scott, Camille, Seaman, Josiah, Sievert, Scott, Simpson, Jared, Skennerton, Connor T, Spencer, James, Srinivasan, Ramakrishnan, Standage, Daniel, Stapleton, James A, Steinman, Susan R, Stein, Joe, Taylor, Benjamin, Trimble, Will, Wiencko, Heather L, Wright, Michael, Wyss, Brian, Zhang, Qingpeng, zyme, en, Brown, C. Titus
• Format: Journal Article
• Language: English
• Published: England F1000Research 2015; F1000 Research Ltd
• Subjects: Bioinformatics; Software Tool; k-mer; streaming; low-memory; bioinformatics; khmer; online; dna sequencing analysis; kmer
• ISSN: 2046-1402; 2046-1402
• DOI: 10.12688/f1000research.6924.1

The khmer package is a freely available software library for working efficiently with fixed length DNA words, or k-mers. khmer provides implementations of a probabilistic k-mer counting data structure, a compressible De Bruijn graph representation, De Bruijn graph partitioning, and digital normalization. khmer is implemented in C++ and Python, and is freely available under the BSD license at  https://github.com/dib-lab/khmer/.