Quantitative tissue sodium concentration mapping of the growth of focal cerebral tumors with sodium magnetic resonance imaging

• Published in: Magnetic resonance in medicine Vol. 41; no. 2; pp. 351 - 359
• Main Authors: Thulborn, Keith R., Davis, Denise, Adams, Holly, Gindin, Tatyana, Zhou, Joe
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01.02.1999; Williams & Wilkins
• Subjects: Animals; Biological and medical sciences; Brain Neoplasms - chemistry; Brain Neoplasms - diagnosis; Brain Neoplasms - radiotherapy; brain tumor; Glioma - chemically induced; Glioma - chemistry; Glioma - radiotherapy; Investigative techniques, diagnostic techniques (general aspects); Magnetic Resonance Imaging; Medical sciences; Nervous system; Phantoms, Imaging; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Radioisotope Dilution Technique; radionuclide dilution assay; rat model; Rats; Rats, Inbred F344; Sodium - analysis; sodium magnetic resonance imaging; tissue sodium concentration; Tumor Cells, Cultured; Cell proliferation; Evaluation; Intracranial; Animal model; Nervous system diseases; Rat; Rodentia; Experimental study; Nuclear magnetic resonance imaging; Cerebral disorder; Vertebrata; Mammalia; Surveillance; Animal; Central nervous system disease; Sodium ion; Tumor; Quantitative analysis
• ISSN: 0740-3194; 1522-2594
• DOI: 10.1002/(SICI)1522-2594(199902)41:2<351::AID-MRM20>3.0.CO;2-H

Tissue sodium concentration (TSC), as determined by in vivo 23Na magnetic resonance imaging (MRI) and the ex vivo classical 22Na radionuclide dilution assay (RDA), has been compared in a rat model of a focal glioma. The 23Na MRI method used a three‐dimensional, twisted projection acquisition scheme at short echo time to minimize signal losses from relaxation of transverse magnetization. Calibration standards within the field of view allowed quantification of the sodium signal in terms of a TSC after correction for B1 nonuniformity and tissue water concentration. The 23Na MRI method measured focally increased TSC values in tumors that were equivalent statistically to the destructive 22Na RDA method. The noninvasive 23Na MRI method provided a quantitative means with which to monitor focal brain tumor growth. Magn Reson Med 41:351–359, 1999. © 1999 Wiley‐Liss, Inc.