The Dynamical Assessment of Inflammatory Biomarkers in Predicting the Outcome of Septic Patients and the Response to Antimicrobial Therapy
To evaluate the kinetics of inflammatory biomarkers in septic patients in order to identify the most reliable predictor of unfavorable outcome. A prospective analysis of septic patients was performed. Median levels of neutrophil/lymphocyte count ratio, fibrinogen, C-reactive protein and procalcitoni...
Saved in:
| Published in | Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) Vol. 6; no. 1; pp. 25 - 31 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Poland
Sciendo
01.01.2020
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | To evaluate the kinetics of inflammatory biomarkers in septic patients in order to identify the most reliable predictor of unfavorable outcome.
A prospective analysis of septic patients was performed. Median levels of neutrophil/lymphocyte count ratio, fibrinogen, C-reactive protein and procalcitonin were dynamically assessed and comparatively analyzed.
Seventy-seven patients were included. Descendent kinetic patterns were registered for all biomarkers, except C-reactive protein. At 24 hours, neutrophil/lymphocyte count ratio significantly decreased in 42.85% of cases, procalcitonin in 37.33%, C-reactive protein in 16.12% and fibrinogen in 1.58% of cases. At 72 hours, procalcitonin decreased to one-half in 70% of cases and neutrophil/lymphocyte count ratio in 67.53% of cases.
Neutrophil/lymphocyte count ratio and procalcitonin significantly decreased in the first 72 hours, while C-reactive protein increased in the first 24 hours. The proportions of patients with major decrease of baseline values were higher for neutrophil/lymphocyte count ratio and procalcitonin. |
|---|---|
| AbstractList | AIMSTo evaluate the kinetics of inflammatory biomarkers in septic patients in order to identify the most reliable predictor of unfavorable outcome. METHODSA prospective analysis of septic patients was performed. Median levels of neutrophil/lymphocyte count ratio, fibrinogen, C-reactive protein and procalcitonin were dynamically assessed and comparatively analyzed. RESULTSSeventy-seven patients were included. Descendent kinetic patterns were registered for all biomarkers, except C-reactive protein. At 24 hours, neutrophil/lymphocyte count ratio significantly decreased in 42.85% of cases, procalcitonin in 37.33%, C-reactive protein in 16.12% and fibrinogen in 1.58% of cases. At 72 hours, procalcitonin decreased to one-half in 70% of cases and neutrophil/lymphocyte count ratio in 67.53% of cases. CONCLUSIONSNeutrophil/lymphocyte count ratio and procalcitonin significantly decreased in the first 72 hours, while C-reactive protein increased in the first 24 hours. The proportions of patients with major decrease of baseline values were higher for neutrophil/lymphocyte count ratio and procalcitonin. Abstract Aims To evaluate the kinetics of inflammatory biomarkers in septic patients in order to identify the most reliable predictor of unfavorable outcome. Methods A prospective analysis of septic patients was performed. Median levels of neutrophil/lymphocyte count ratio, fibrinogen, C-reactive protein and procalcitonin were dynamically assessed and comparatively analyzed. Results Seventy-seven patients were included. Descendent kinetic patterns were registered for all biomarkers, except C-reactive protein. At 24 hours, neutrophil/lymphocyte count ratio significantly decreased in 42.85% of cases, procalcitonin in 37.33%, C-reactive protein in 16.12% and fibrinogen in 1.58% of cases. At 72 hours, procalcitonin decreased to one-half in 70% of cases and neutrophil/lymphocyte count ratio in 67.53% of cases. Conclusions Neutrophil/lymphocyte count ratio and procalcitonin significantly decreased in the first 72 hours, while C-reactive protein increased in the first 24 hours. The proportions of patients with major decrease of baseline values were higher for neutrophil/lymphocyte count ratio and procalcitonin. To evaluate the kinetics of inflammatory biomarkers in septic patients in order to identify the most reliable predictor of unfavorable outcome. A prospective analysis of septic patients was performed. Median levels of neutrophil/lymphocyte count ratio, fibrinogen, C-reactive protein and procalcitonin were dynamically assessed and comparatively analyzed. Seventy-seven patients were included. Descendent kinetic patterns were registered for all biomarkers, except C-reactive protein. At 24 hours, neutrophil/lymphocyte count ratio significantly decreased in 42.85% of cases, procalcitonin in 37.33%, C-reactive protein in 16.12% and fibrinogen in 1.58% of cases. At 72 hours, procalcitonin decreased to one-half in 70% of cases and neutrophil/lymphocyte count ratio in 67.53% of cases. Neutrophil/lymphocyte count ratio and procalcitonin significantly decreased in the first 72 hours, while C-reactive protein increased in the first 24 hours. The proportions of patients with major decrease of baseline values were higher for neutrophil/lymphocyte count ratio and procalcitonin. To evaluate the kinetics of inflammatory biomarkers in septic patients in order to identify the most reliable predictor of unfavorable outcome. |
| Author | Tilişcan, Cătălin Orfanu, Alina Aramă, Victoria Popescu, Cristina Aramă, Ştefan Sorin Streinu-Cercel, Adrian |
| Author_xml | – sequence: 1 givenname: Alina surname: Orfanu fullname: Orfanu, Alina email: alina.lobodan@yahoo.com organization: University of Medicine and Pharmacy "Carol Davila", Bucharest Romania – sequence: 2 givenname: Victoria surname: Aramă fullname: Aramă, Victoria organization: University of Medicine and Pharmacy "Carol Davila", Bucharest Romania – sequence: 3 givenname: Cristina surname: Popescu fullname: Popescu, Cristina organization: University of Medicine and Pharmacy "Carol Davila", Bucharest Romania – sequence: 4 givenname: Cătălin surname: Tilişcan fullname: Tilişcan, Cătălin organization: University of Medicine and Pharmacy "Carol Davila", Bucharest Romania – sequence: 5 givenname: Adrian surname: Streinu-Cercel fullname: Streinu-Cercel, Adrian organization: University of Medicine and Pharmacy "Carol Davila", Bucharest Romania – sequence: 6 givenname: Ştefan Sorin surname: Aramă fullname: Aramă, Ştefan Sorin organization: University of Medicine and Pharmacy "Carol Davila", Bucharest Romania |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32104728$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1kk1v1DAQhiNUREvplSPykUuKv2I7HJCW8rVSpVZQzpbj2Fsvib21HVD-Ar8ap1tW9MDJI_udZ2Y87_PqyAdvquolgueYcvFmq_VYY4hhDSGkT6oTTFpSI4H40SGG7XF1ltK2KBAnvG3Es-qYYAQpx-Kk-n1za8CH2avRaTWAVUompdH4DIIFa28HNY4qhziD9y6MKv4wMQHnwXU0vdPZ-Q3IhXA1ZR1GsyR9M7vsNLhW2RVMAsr395KvJu2CTwbkAFY-u1Iwhs6VoqWFqHbzi-qpVUMyZw_nafX908ebiy_15dXn9cXqstYN5Lm2tre4UYxS2nFBLesahDlvcM8FM0whRASjvWYtXUJlUdNp2Lek65iAFJPTar3n9kFt5S66MtYsg3Ly_iLEjVSxjDAYqVnfNsRgbTGnjYUdQZpyZBtmBRJdV1jv9qzd1I2m12XiqIZH0Mcv3t3KTfgpOcQthaIAXj8AYribTMpydEmbYVDehClJTBhjBBNOi_R8Ly3_llI09lAGQbn4QS5-kIsf5OKHkvDq3-YO8r_bL4K3e8EvNWQTe7OJ01wCuQ1T9GUH_yEzhBvyB4AryFw |
| CitedBy_id | crossref_primary_10_1097_PTS_0000000000001069 crossref_primary_10_1097_MBC_0000000000001197 |
| Cites_doi | 10.2478/s11536-012-0002-3 10.1309/AJCP1MFYINQLECV2 10.1097/CCM.0000000000002924 10.1093/ofid/ofy029 10.1016/j.ejca.2017.11.012 10.1007/s00167-015-3921-0 10.1038/pr.2013.124 10.1371/journal.pone.0212861 10.4103/0972-5229.152755 10.1111/1574-6976.12080 10.5935/0103-507X.20150044 10.3325/cmj.2012.53.30 10.1155/2016/8191254 10.1136/jclinpath-2014-202807 10.5114/aoms.2016.57587 10.30699/ijp.13.2.272 10.1186/cc7751 10.1038/s41372-019-0363-4 10.1186/cc12896 10.1093/ofid/ofv098 10.1371/journal.pone.0181704 10.1186/cc13399 10.1086/650580 10.4103/0972-5229.186226 10.1001/jama.2016.0287 10.1016/j.jot.2017.05.008 |
| ContentType | Journal Article |
| Copyright | 2020 Alina Orfanu, Victoria Aramă, Cristina Popescu, Cătălin Tilişcan, Adrian Streinu-Cercel, Ştefan Sorin Aramă, published by Sciendo. 2020 Alina Orfanu, Victoria Aramă, Cristina Popescu, Cătălin Tilişcan, Adrian Streinu-Cercel, Ştefan Sorin Aramă, published by Sciendo 2020 Alina Orfanu, Victoria Aramă, Cristina Popescu, Cătălin Tilişcan, Adrian Streinu-Cercel, Ştefan Sorin Aramă, published by Sciendo |
| Copyright_xml | – notice: 2020 Alina Orfanu, Victoria Aramă, Cristina Popescu, Cătălin Tilişcan, Adrian Streinu-Cercel, Ştefan Sorin Aramă, published by Sciendo. – notice: 2020 Alina Orfanu, Victoria Aramă, Cristina Popescu, Cătălin Tilişcan, Adrian Streinu-Cercel, Ştefan Sorin Aramă, published by Sciendo 2020 Alina Orfanu, Victoria Aramă, Cristina Popescu, Cătălin Tilişcan, Adrian Streinu-Cercel, Ştefan Sorin Aramă, published by Sciendo |
| DBID | NPM AAYXX CITATION 7X8 5PM DOA |
| DOI | 10.2478/jccm-2020-0004 |
| DatabaseName | PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic CrossRef PubMed |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ - Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 2393-1817 |
| EndPage | 31 |
| ExternalDocumentID | oai_doaj_org_article_c6d953e2cf2745f0b31c471f56f818bb 10_2478_jccm_2020_0004 32104728 10_2478_jccm_2020_00046125 |
| Genre | Journal Article |
| GroupedDBID | 4.4 53G 9WM ABFKT ACGFS ADBBV ADBLJ AHGSO ALMA_UNASSIGNED_HOLDINGS AOIJS BCNDV EBS GROUPED_DOAJ HYE KQ8 M~E OK1 QD8 RPM NPM AAYXX CITATION 7X8 5PM |
| ID | FETCH-LOGICAL-c507t-ffdf25a6444b784f6b5127752d786e6a113864dc6941138af15bc0d93bb680423 |
| IEDL.DBID | RPM |
| ISSN | 2393-1809 2393-1817 |
| IngestDate | Thu Jul 04 21:04:26 EDT 2024 Fri Sep 01 02:35:15 EDT 2023 Thu Apr 11 23:12:58 EDT 2024 Fri Aug 23 02:16:55 EDT 2024 Wed Jun 21 11:46:03 EDT 2023 Thu Jul 14 15:50:05 EDT 2022 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | biomarkers of inflammation kinetic patterns prognosis therapy response sepsis |
| Language | English |
| License | This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. 2020 Alina Orfanu, Victoria Aramă, Cristina Popescu, Cătălin Tilişcan, Adrian Streinu-Cercel, Ştefan Sorin Aramă, published by Sciendo. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c507t-ffdf25a6444b784f6b5127752d786e6a113864dc6941138af15bc0d93bb680423 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029408/ |
| PMID | 32104728 |
| PQID | 2366632374 |
| PQPubID | 23479 |
| PageCount | 7 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_c6d953e2cf2745f0b31c471f56f818bb pubmedcentral_primary_oai_pubmedcentral_nih_gov_7029408 proquest_miscellaneous_2366632374 crossref_primary_10_2478_jccm_2020_0004 pubmed_primary_32104728 walterdegruyter_journals_10_2478_jccm_2020_00046125 |
| PublicationCentury | 2000 |
| PublicationDate | 2020-01-01 |
| PublicationDateYYYYMMDD | 2020-01-01 |
| PublicationDate_xml | – month: 01 year: 2020 text: 2020-01-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | Poland |
| PublicationPlace_xml | – name: Poland |
| PublicationTitle | Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) |
| PublicationTitleAlternate | J Crit Care Med (Targu Mures) |
| PublicationYear | 2020 |
| Publisher | Sciendo |
| Publisher_xml | – name: Sciendo |
| References | Phua, J; Ngerng, W; See, K; Tay, C; Kiong, T; Lim, H (j_jccm-2020-0004_ref_002) 2013; 17 Kethireddy, S; Bilgili, B; Sees, A; Kirchner, H; Ofoma, U; Light, R (j_jccm-2020-0004_ref_003) 2018; 46 Ameratunga, M; Chenard‐Poirier, M; Moreno, Candilejo I; Pedregal, M; Lui, A; Dolling, D (j_jccm-2020-0004_ref_020) 2018; 89 Berends, ET; Kuipers, A; Ravesloot, MM; Urbanus, RT; Rooijakkers, SH (j_jccm-2020-0004_ref_009) 2014; 38 Lipińska-Gediga, M; Mierzchała-Pasierb, M; Durek, G (j_jccm-2020-0004_ref_028) 2016; 12 Pradhan, S; Ghimire, A; Bhatarai, B; Khanal, B; Pokharel, K; Lamsal, M (j_jccm-2020-0004_ref_024) 2016; 20 Sharma, A; Sikka, M; Gomber, S; Sharma, S (j_jccm-2020-0004_ref_022) 2018; 13 Wasko, MK; Struminski, M; Bobecka-Wesolowska, K; Kowalczewski, J (j_jccm-2020-0004_ref_012) 2017; 10 Heffner, AC; Horton, JM; Marchick, MR; Jones, AE (j_jccm-2020-0004_ref_015) 2010; 50 Ljungström, L; Pernestig, AK; Jacobsson, G; Andersson, R; Usener, B; Tilevik, D (j_jccm-2020-0004_ref_017) 2017; 12 Previsdomini, M; Gini, M; Cerutti, B; Dolina, M; Perren, A (j_jccm-2020-0004_ref_001) 2012; 53 Azfar, M; Khan, M; Khurshid, M (j_jccm-2020-0004_ref_023) 2014; 18 Davidson, J; Tong, S; Hauck, A; Lawson, DS; da, Cruz E; Kaufman, J (j_jccm-2020-0004_ref_007) 2013; 74 Riedel, S; Melendez, JH; An, AT; Rosenbaum, JE; Zenilman, JM (j_jccm-2020-0004_ref_005) 2011; 135 Westerdijk, K; Simons, KS; Zegers, M; Wever, PC; Pickkers, P; de, Jager CPC (j_jccm-2020-0004_ref_018); 14 Holub, M.; Beran, O.; Kaspříková, N; Chalupa, P (j_jccm-2020-0004_ref_021) 2012; 7 Yombi, JC; Schwab, PE; Thienpont, E (j_jccm-2020-0004_ref_019) 2016; 24 Davies, J (j_jccm-2020-0004_ref_026) 2015; 68 Zahorec, R (j_jccm-2020-0004_ref_011) 2001; 102 Singer, M; Deutschman, CS; Seymour, CW; Shankar-Hari, M; Annane, D; Bauer, M (j_jccm-2020-0004_ref_013) 2016; 315 Eschborn, S; Weitkamp, JH (j_jccm-2020-0004_ref_008) 2019; 39 Poddar, B; Gurjar, M; Singh, S; Aggarwal, A; Singh, R; Azim, A (j_jccm-2020-0004_ref_027) 2015; 19 Markanday, A (j_jccm-2020-0004_ref_006) 2015; 2 Charles, PE; Tinel, C; Barbar, S; Aho, S; Prin, S; Doise, JM (j_jccm-2020-0004_ref_025) 2009; 13 Pedro, TCS; Morcillo, AM; Baracat, ECE (j_jccm-2020-0004_ref_014) 2015; 27 Jenkins, TC; Haukoos, JS; Coton, E; Weitzenkamp, D; Frank, DN; Burman, WJ (j_jccm-2020-0004_ref_004) 2018; 5 2024041820094827425_j_jccm-2020-0004_ref_019_w2aab2b8c39b1b7b1ab2b2c19Aa 2024041820094827425_j_jccm-2020-0004_ref_021_w2aab2b8c39b1b7b1ab2b2c21Aa 2024041820094827425_j_jccm-2020-0004_ref_003_w2aab2b8c39b1b7b1ab2b2b3Aa 2024041820094827425_j_jccm-2020-0004_ref_025_w2aab2b8c39b1b7b1ab2b2c25Aa 2024041820094827425_j_jccm-2020-0004_ref_014_w2aab2b8c39b1b7b1ab2b2c14Aa 2024041820094827425_j_jccm-2020-0004_ref_007_w2aab2b8c39b1b7b1ab2b2b7Aa 2024041820094827425_j_jccm-2020-0004_ref_010_w2aab2b8c39b1b7b1ab2b2c10Aa 2024041820094827425_j_jccm-2020-0004_ref_018_w2aab2b8c39b1b7b1ab2b2c18Aa 2024041820094827425_j_jccm-2020-0004_ref_022_w2aab2b8c39b1b7b1ab2b2c22Aa 2024041820094827425_j_jccm-2020-0004_ref_002_w2aab2b8c39b1b7b1ab2b2b2Aa 2024041820094827425_j_jccm-2020-0004_ref_015_w2aab2b8c39b1b7b1ab2b2c15Aa 2024041820094827425_j_jccm-2020-0004_ref_026_w2aab2b8c39b1b7b1ab2b2c26Aa 2024041820094827425_j_jccm-2020-0004_ref_006_w2aab2b8c39b1b7b1ab2b2b6Aa 2024041820094827425_j_jccm-2020-0004_ref_011_w2aab2b8c39b1b7b1ab2b2c11Aa 2024041820094827425_j_jccm-2020-0004_ref_012_w2aab2b8c39b1b7b1ab2b2c12Aa 2024041820094827425_j_jccm-2020-0004_ref_009_w2aab2b8c39b1b7b1ab2b2b9Aa 2024041820094827425_j_jccm-2020-0004_ref_017_w2aab2b8c39b1b7b1ab2b2c17Aa 2024041820094827425_j_jccm-2020-0004_ref_028_w2aab2b8c39b1b7b1ab2b2c28Aa 2024041820094827425_j_jccm-2020-0004_ref_001_w2aab2b8c39b1b7b1ab2b2b1Aa 2024041820094827425_j_jccm-2020-0004_ref_023_w2aab2b8c39b1b7b1ab2b2c23Aa 2024041820094827425_j_jccm-2020-0004_ref_005_w2aab2b8c39b1b7b1ab2b2b5Aa 2024041820094827425_j_jccm-2020-0004_ref_013_w2aab2b8c39b1b7b1ab2b2c13Aa 2024041820094827425_j_jccm-2020-0004_ref_008_w2aab2b8c39b1b7b1ab2b2b8Aa 2024041820094827425_j_jccm-2020-0004_ref_027_w2aab2b8c39b1b7b1ab2b2c27Aa 2024041820094827425_j_jccm-2020-0004_ref_016_w2aab2b8c39b1b7b1ab2b2c16Aa 2024041820094827425_j_jccm-2020-0004_ref_020_w2aab2b8c39b1b7b1ab2b2c20Aa 2024041820094827425_j_jccm-2020-0004_ref_004_w2aab2b8c39b1b7b1ab2b2b4Aa 2024041820094827425_j_jccm-2020-0004_ref_024_w2aab2b8c39b1b7b1ab2b2c24Aa |
| References_xml | – volume: 46 start-page: 506 issue: 4 year: 2018 end-page: 512 ident: j_jccm-2020-0004_ref_003 article-title: Culture-Negative Septic Shock Compared With Culture-Positive Septic Shock: A Retrospective Cohort Study publication-title: Crit Care Med contributor: fullname: Kethireddy, S; Bilgili, B; Sees, A; Kirchner, H; Ofoma, U; Light, R – volume: 50 start-page: 814 issue: 6 year: 2010 end-page: 820 ident: j_jccm-2020-0004_ref_015 article-title: Etiology of illness in patients with severe sepsis admitted to the hospital from the emergency department publication-title: Clin Infect Dis contributor: fullname: Heffner, AC; Horton, JM; Marchick, MR; Jones, AE – volume: 7 start-page: 258 issue: 2 year: 2012 end-page: 61 ident: j_jccm-2020-0004_ref_021 article-title: Neutrophil to lymphocyte count ratio as a biomarker of bacterial infections publication-title: Cent Eur J Med contributor: fullname: Holub, M.; Beran, O.; Kaspříková, N; Chalupa, P – volume: 89 start-page: 56 year: 2018 end-page: 63 ident: j_jccm-2020-0004_ref_020 article-title: Neutrophil‐lymphocyte ratio kinetics in patients with advanced solid tumours on phase I trials of PD‐1/PD‐L1 inhibitors publication-title: Eur J Cancer contributor: fullname: Ameratunga, M; Chenard‐Poirier, M; Moreno, Candilejo I; Pedregal, M; Lui, A; Dolling, D – volume: 10 start-page: 36 year: 2017 end-page: 41 ident: j_jccm-2020-0004_ref_012 article-title: Neutrophil-to-lymphocyte ratio shows faster changing kinetics than C-reactive protein after total hip and knee arthroplasty publication-title: J Orthop Translat contributor: fullname: Wasko, MK; Struminski, M; Bobecka-Wesolowska, K; Kowalczewski, J – volume: 17 start-page: R202 issue: 5 year: 2013 ident: j_jccm-2020-0004_ref_002 article-title: Characteristics and outcomes of culture-negative versus culture-positive severe sepsis publication-title: Crit Care contributor: fullname: Phua, J; Ngerng, W; See, K; Tay, C; Kiong, T; Lim, H – volume: 5 start-page: ofy029 issue: 3 year: 2018 ident: j_jccm-2020-0004_ref_004 article-title: Time Course of C-Reactive Protein and Procalcitonin Levels During the Treatment of Acute Bacterial Skin Infections publication-title: Open Forum Infect Dis contributor: fullname: Jenkins, TC; Haukoos, JS; Coton, E; Weitzenkamp, D; Frank, DN; Burman, WJ – volume: 12 start-page: e0181704 issue: 7 year: 2017 ident: j_jccm-2020-0004_ref_017 article-title: Diagnostic accuracy of procalcitonin, neutrophil-lymphocyte count ratio, C-reactive protein, and lactate in patients with suspected bacterial sepsis publication-title: PLoS One contributor: fullname: Ljungström, L; Pernestig, AK; Jacobsson, G; Andersson, R; Usener, B; Tilevik, D – volume: 39 start-page: 893 issue: 7 year: 2019 end-page: 903 ident: j_jccm-2020-0004_ref_008 article-title: Procalcitonin versus C-reactive protein: review of kinetics and performance for diagnosis of neonatal sepsis publication-title: J Perinatol contributor: fullname: Eschborn, S; Weitkamp, JH – volume: 14 start-page: e0212861 issue: 2 ident: j_jccm-2020-0004_ref_018 article-title: The value of the neutrophil-lymphocyte count ratio in the diagnosis of sepsis in patients admitted to the Intensive Care Unit: A retrospective cohort study publication-title: PLoS ONE contributor: fullname: Westerdijk, K; Simons, KS; Zegers, M; Wever, PC; Pickkers, P; de, Jager CPC – volume: 13 start-page: 272 issue: 2 year: 2018 end-page: 275 ident: j_jccm-2020-0004_ref_022 article-title: Plasma Fibrinogen and D-dimer in Children With Sepsis: A Single-Center Experience publication-title: Iran J Pathol contributor: fullname: Sharma, A; Sikka, M; Gomber, S; Sharma, S – volume: 68 start-page: 675 issue: 9 year: 2015 end-page: 9 ident: j_jccm-2020-0004_ref_026 article-title: Procalcitonin publication-title: J Clin Pathol contributor: fullname: Davies, J – volume: 19 start-page: 140 issue: 3 year: 2015 end-page: 146 ident: j_jccm-2020-0004_ref_027 article-title: Procalcitonin kinetics as a prognostic marker in severe sepsis/ septic shock publication-title: Indian J Crit Care Med contributor: fullname: Poddar, B; Gurjar, M; Singh, S; Aggarwal, A; Singh, R; Azim, A – volume: 13 start-page: R38 issue: 2 year: 2009 ident: j_jccm-2020-0004_ref_025 article-title: Procalcitonin kinetics within the first days of sepsis: relationship with the appropriateness of antibiotic therapy and the outcome publication-title: Crit Care contributor: fullname: Charles, PE; Tinel, C; Barbar, S; Aho, S; Prin, S; Doise, JM – volume: 27 start-page: 240 issue: 3 year: 2015 end-page: 246 ident: j_jccm-2020-0004_ref_014 article-title: Etiology and prognostic factors of sepsis among children and adolescents admitted to the intensive care unit. Rev publication-title: bras. ter. intensiva [online] contributor: fullname: Pedro, TCS; Morcillo, AM; Baracat, ECE – volume: 18 start-page: P209 issue: 1 year: 2014 ident: j_jccm-2020-0004_ref_023 article-title: Fibrinogen at admission is an independent predictor of mortality in severe sepsis and septic shock publication-title: Crit Care contributor: fullname: Azfar, M; Khan, M; Khurshid, M – volume: 53 start-page: 30 issue: 1 year: 2012 end-page: 39 ident: j_jccm-2020-0004_ref_001 article-title: Predictors of positive blood cultures in critically ill patients: a retrospective evaluation publication-title: Croat Med J contributor: fullname: Previsdomini, M; Gini, M; Cerutti, B; Dolina, M; Perren, A – volume: 38 start-page: 1146 year: 2014 end-page: 1171 ident: j_jccm-2020-0004_ref_009 article-title: Bacteria under stress by complement and coagulation publication-title: FEMS Microbiol Rev contributor: fullname: Berends, ET; Kuipers, A; Ravesloot, MM; Urbanus, RT; Rooijakkers, SH – volume: 20 start-page: 417 issue: 7 year: 2016 end-page: 420 ident: j_jccm-2020-0004_ref_024 article-title: The role of C-reactive protein as a diagnostic predictor of sepsis in a multidisciplinary Intensive Care Unit of a tertiary care center in Nepal publication-title: Indian J Crit Care Med contributor: fullname: Pradhan, S; Ghimire, A; Bhatarai, B; Khanal, B; Pokharel, K; Lamsal, M – volume: 315 start-page: 801 issue: 8 year: 2016 end-page: 10 ident: j_jccm-2020-0004_ref_013 article-title: The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) publication-title: JAMA contributor: fullname: Singer, M; Deutschman, CS; Seymour, CW; Shankar-Hari, M; Annane, D; Bauer, M – volume: 2 start-page: ofv098 issue: 3 year: 2015 ident: j_jccm-2020-0004_ref_006 article-title: Acute Phase Reactants in Infections: Evidence-Based Review and a Guide for Clinicians publication-title: Open Forum Infect Dis contributor: fullname: Markanday, A – volume: 74 start-page: 413 issue: 4 year: 2013 end-page: 419 ident: j_jccm-2020-0004_ref_007 article-title: Kinetics of procalcitonin and C-reactive protein and the relationship to postoperative infection in young infants undergoing cardiovascular surgery publication-title: Pediatr Res contributor: fullname: Davidson, J; Tong, S; Hauck, A; Lawson, DS; da, Cruz E; Kaufman, J – volume: 102 start-page: 5 issue: 1 year: 2001 end-page: 14 ident: j_jccm-2020-0004_ref_011 article-title: Ratio of neutrophil to lymphocyte counts–rapid and simple parameter of systemic inflammation and stress in critically ill publication-title: Bratisl Lek Listy contributor: fullname: Zahorec, R – volume: 24 start-page: 3287 issue: 10 year: 2016 end-page: 3292 ident: j_jccm-2020-0004_ref_019 article-title: Neutrophil-to-lymphocyte ratio (NLR) distribution shows a beter kinetic patern than C-reactive protein distribution for the follow-up of early inflammation after total knee arthroplasty publication-title: Knee Surg Sports Traumatol Arthrosc contributor: fullname: Yombi, JC; Schwab, PE; Thienpont, E – volume: 12 start-page: 112 issue: 1 year: 2016 end-page: 9 ident: j_jccm-2020-0004_ref_028 article-title: Procalcitonin kinetics - prognostic and diagnostic significance in septic patients publication-title: Arch Med Sci contributor: fullname: Lipińska-Gediga, M; Mierzchała-Pasierb, M; Durek, G – volume: 135 start-page: 182 issue: 2 year: 2011 end-page: 9 ident: j_jccm-2020-0004_ref_005 article-title: Procalcitonin as a marker for the detection of bacteremia and sepsis in the emergency department publication-title: Am J Clin Pathol contributor: fullname: Riedel, S; Melendez, JH; An, AT; Rosenbaum, JE; Zenilman, JM – ident: 2024041820094827425_j_jccm-2020-0004_ref_021_w2aab2b8c39b1b7b1ab2b2c21Aa doi: 10.2478/s11536-012-0002-3 – ident: 2024041820094827425_j_jccm-2020-0004_ref_005_w2aab2b8c39b1b7b1ab2b2b5Aa doi: 10.1309/AJCP1MFYINQLECV2 – ident: 2024041820094827425_j_jccm-2020-0004_ref_003_w2aab2b8c39b1b7b1ab2b2b3Aa doi: 10.1097/CCM.0000000000002924 – ident: 2024041820094827425_j_jccm-2020-0004_ref_010_w2aab2b8c39b1b7b1ab2b2c10Aa – ident: 2024041820094827425_j_jccm-2020-0004_ref_004_w2aab2b8c39b1b7b1ab2b2b4Aa doi: 10.1093/ofid/ofy029 – ident: 2024041820094827425_j_jccm-2020-0004_ref_020_w2aab2b8c39b1b7b1ab2b2c20Aa doi: 10.1016/j.ejca.2017.11.012 – ident: 2024041820094827425_j_jccm-2020-0004_ref_019_w2aab2b8c39b1b7b1ab2b2c19Aa doi: 10.1007/s00167-015-3921-0 – ident: 2024041820094827425_j_jccm-2020-0004_ref_007_w2aab2b8c39b1b7b1ab2b2b7Aa doi: 10.1038/pr.2013.124 – ident: 2024041820094827425_j_jccm-2020-0004_ref_018_w2aab2b8c39b1b7b1ab2b2c18Aa doi: 10.1371/journal.pone.0212861 – ident: 2024041820094827425_j_jccm-2020-0004_ref_027_w2aab2b8c39b1b7b1ab2b2c27Aa doi: 10.4103/0972-5229.152755 – ident: 2024041820094827425_j_jccm-2020-0004_ref_009_w2aab2b8c39b1b7b1ab2b2b9Aa doi: 10.1111/1574-6976.12080 – ident: 2024041820094827425_j_jccm-2020-0004_ref_014_w2aab2b8c39b1b7b1ab2b2c14Aa doi: 10.5935/0103-507X.20150044 – ident: 2024041820094827425_j_jccm-2020-0004_ref_001_w2aab2b8c39b1b7b1ab2b2b1Aa doi: 10.3325/cmj.2012.53.30 – ident: 2024041820094827425_j_jccm-2020-0004_ref_016_w2aab2b8c39b1b7b1ab2b2c16Aa doi: 10.1155/2016/8191254 – ident: 2024041820094827425_j_jccm-2020-0004_ref_026_w2aab2b8c39b1b7b1ab2b2c26Aa doi: 10.1136/jclinpath-2014-202807 – ident: 2024041820094827425_j_jccm-2020-0004_ref_028_w2aab2b8c39b1b7b1ab2b2c28Aa doi: 10.5114/aoms.2016.57587 – ident: 2024041820094827425_j_jccm-2020-0004_ref_022_w2aab2b8c39b1b7b1ab2b2c22Aa doi: 10.30699/ijp.13.2.272 – ident: 2024041820094827425_j_jccm-2020-0004_ref_025_w2aab2b8c39b1b7b1ab2b2c25Aa doi: 10.1186/cc7751 – ident: 2024041820094827425_j_jccm-2020-0004_ref_008_w2aab2b8c39b1b7b1ab2b2b8Aa doi: 10.1038/s41372-019-0363-4 – ident: 2024041820094827425_j_jccm-2020-0004_ref_002_w2aab2b8c39b1b7b1ab2b2b2Aa doi: 10.1186/cc12896 – ident: 2024041820094827425_j_jccm-2020-0004_ref_006_w2aab2b8c39b1b7b1ab2b2b6Aa doi: 10.1093/ofid/ofv098 – ident: 2024041820094827425_j_jccm-2020-0004_ref_017_w2aab2b8c39b1b7b1ab2b2c17Aa doi: 10.1371/journal.pone.0181704 – ident: 2024041820094827425_j_jccm-2020-0004_ref_023_w2aab2b8c39b1b7b1ab2b2c23Aa doi: 10.1186/cc13399 – ident: 2024041820094827425_j_jccm-2020-0004_ref_015_w2aab2b8c39b1b7b1ab2b2c15Aa doi: 10.1086/650580 – ident: 2024041820094827425_j_jccm-2020-0004_ref_024_w2aab2b8c39b1b7b1ab2b2c24Aa doi: 10.4103/0972-5229.186226 – ident: 2024041820094827425_j_jccm-2020-0004_ref_011_w2aab2b8c39b1b7b1ab2b2c11Aa – ident: 2024041820094827425_j_jccm-2020-0004_ref_013_w2aab2b8c39b1b7b1ab2b2c13Aa doi: 10.1001/jama.2016.0287 – ident: 2024041820094827425_j_jccm-2020-0004_ref_012_w2aab2b8c39b1b7b1ab2b2c12Aa doi: 10.1016/j.jot.2017.05.008 |
| SSID | ssj0001737958 ssib035722990 ssib044789095 |
| Score | 2.1702235 |
| Snippet | To evaluate the kinetics of inflammatory biomarkers in septic patients in order to identify the most reliable predictor of unfavorable outcome.
A prospective... Abstract Aims To evaluate the kinetics of inflammatory biomarkers in septic patients in order to identify the most reliable predictor of unfavorable outcome.... AIMSTo evaluate the kinetics of inflammatory biomarkers in septic patients in order to identify the most reliable predictor of unfavorable outcome. METHODSA... To evaluate the kinetics of inflammatory biomarkers in septic patients in order to identify the most reliable predictor of unfavorable outcome. |
| SourceID | doaj pubmedcentral proquest crossref pubmed walterdegruyter |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 25 |
| SubjectTerms | biomarkers of inflammation kinetic patterns prognosis sepsis therapy response |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQDxWXCsprKSAjIXGKmvidYwtUBalQQSv1FsUvCNIm1W5WiL_Ar2bGzq66PMSFW5T4mflsz3jGnwl5EVtVxsDLonISSbW9LayrY8EjrxxTrZUOzzufvVenl-Ldlby6cdUXxoRleuD84w6d8rXkgbkI9pOMpYUyYEKNUkVYa6xNs28lbxhTaXdFc11Lk1kamdDm8Ktzc4AEy-eot1ahRNb_Jw3z90DJvW_Jie3D58Xq-7h2mqa16OQO2ZuUSHqUG3-X3Ar9Ptk9m9zk98gPED59ne-ax3Qb9k06RPq2j4CCefKu0-NumGOAzmJJu56eL7AIDISmoBfSD6sR8Bgw0ycMfnH0PLOwLmnb-5TkYw6xDXQc6FE_dvMuETtBpReZruA-uTx5c_HqtJguXSgcqIZjEaOPTLagJgmrjYjKgkqgtWReGxVUW1XcKOEdHoCFxzZW0rrS19xaZTDI5gHZ6Yc-PCLUBOWD51VgoRLOxJqLIGpj2uAUmK3VjLxcC6G5ztwaDdgkKK4GxdWguNA7LmbkGGW0SYWc2OkFIKWZkNL8Cykz8nwt4QbGEDpG2j4Mq2XDOBhxnHENFT3MEt9UhWechGZmRvQWFrbasv2l774knm5dslqUkJP_gppmmieWf-kuap2P_0eXD8jtDHncMnpCdsbFKjwFJWq0z9J4-QkMlR3I priority: 102 providerName: Directory of Open Access Journals |
| Title | The Dynamical Assessment of Inflammatory Biomarkers in Predicting the Outcome of Septic Patients and the Response to Antimicrobial Therapy |
| URI | http://www.degruyter.com/doi/10.2478/jccm-2020-0004 https://www.ncbi.nlm.nih.gov/pubmed/32104728 https://search.proquest.com/docview/2366632374 https://pubmed.ncbi.nlm.nih.gov/PMC7029408 https://doaj.org/article/c6d953e2cf2745f0b31c471f56f818bb |
| Volume | 6 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELbaHqpeKt4sj8pISJzSTfxMjm1pVUALC7RSb1Hs2CWIJNVuVogLP4BfzYyTrFgeFy7RbtYbx5ov8Yznm8-EPPeFir3jcZRYiaLapYmMzXzEPU8sU4WRFuudZ2_V-aV4fSWvtogca2ECad-a6rD5Uh821afArbyp7XTkiU3nsxMds0zE6XSbbGvON0N0LjXDV-z4XQgs9RyKT8PCi-Y6C_t2ovpXhPpVvZgjg5bTz9bWgBzWl1vvkV2scREaN2v_Zd4K8v5_80n_pFbufw1p79JdL1bfujHNGmavs1tkf3A76VE_vNtkyzV3yO5sSKzfJT8ALvRlvzs9tlvrddLW01eNB9zUIR9Pj6u2RkrPYkmrhs4XeAmkTlPwJOm7VQcIdvinj0iXsXTe67YuadGUocmHnpTraNfSo6ar6ipIQUGnF73AwT1yeXZ6cXIeDds0RBacyS7yvvRMFuBYCaNT4ZUBJ0JryUqdKqeKJOGpEqXFkln4WPhEGhuXGTdGpUjLuU92mrZxDwlNnSpdyRPHXCJs6jMunMjStHBWQaCbTMiL0Qj5Ta_GkUMUg5bL0XI5Wg7z6WJCjtFG61aooh1OtIvrfMBSblWZSe6Y9RCbSx8bwCdM1l4qD36MMRPybLRwDk8dplKKxrWrZc44hH2ccQ0dPegtvu5qRMyE6A0sbNzL5i8A9KDsPQB7QvhvqMmHN8vyH8NFP_XRf_f3mOz1kMeVpSdkp1us3FPwtTpzENYo4PjmfQrH2ffTg_C0_QSplipH |
| link.rule.ids | 230,315,733,786,790,870,891,2115,27955,27956,53825,53827,76520,76521 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLZGJwEvE3fK1UhIPEVLfM9jB4wO1m1inbS3KL6NIDVBaSrEX-BXc-ykRYXxwluU2LGT7zj-nHPOZ4Re-1Kk3tE0yQwPotpWJ9rkPqGeZoaIUnMT8p1nJ2J6wT5e8ssdRNa5MPG7b6O3cn94dzFcmUm1_9WYBaBK-lToG2hXCk7SEdqdTD-cn_7-syKpzLnqFRqvqbg1A0Wh_uvY5d9BknvfowPbuqt29aNbO0zjPHR4B-0NBBJP-l7fRTuuvoduzgYX-X30E4DH7_p95kO5jfImbjw-qj1YwCJ61vFB1SxCcE67xFWNz9pwixAEjYET4tNVBy_HhUrnIfDF4LNegXWJy9rGIp_78FqHuwZP6q5aVFHUCRqd91IFD9DF4fv522kybLiQGKCFXeK99YSXQJGYlop5oYEOSMmJlUo4UWYZVYJZE5Jf4bD0GdcmtTnVWqgQYPMQjeqmdo8RVk5YZ2nmiMuYUT6nzLFcqdIZAUvWbIzerEEovvW6GgWsRwJcRYCrCHAFzzgbo4OA0aZU0MOOJ5r2qhhMpDDC5pw6YjyssrlPNVgaTLueCw-MROsxerVGuIDxE5wiZe2a1bIgFBZwlFAJDT3qEd80FfKbmCRqjOSWLWz1ZftKXX2JGt0yJTlLoSb9w2qK4Rux_MfjBsb55L9qvUS3pvPZcXF8dPLpKbrd23v4V_QMjbp25Z4De-r0i2G4_AK6MRo2 |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZgK1VcKt4sTyMhcYqaxI7tHLeUZQu0XdFW6i2KXyVIm1TZrBB_gV_NjJNdtFAu3KLEjpN8dvyNZ-YzIW98KWLvWBwlJkNRbasjbXIfMc8Sk4pSZwbznY9PxOyCf7zMLgdDEXNhwn_fBm_l_rX1IVSZS7X_zZgFIJr2adC3yY4UMPGMyM5k9uHs9PeqimQyz1SvznhDxa3ZJ4j038Qs_w6Q3PsenNfWXbWrH93aWRrmoOldsjeQRzrp0b5Hbrn6Ptk9HtzjD8hPAJ0e9nvMY7mN6iZtPD2qPaC_CF51elA1CwzMaZe0qum8xVtgADQFPkhPVx18GIeVzjDoxdB5r766pGVtQ5EvfWito11DJ3VXLaog6ASNnvcyBQ_JxfT9-btZNGy2EBmghF3kvfVpVgI94loq7oUGKiBlllqphBNlkjAluDWY-AqHpU8ybWKbM62FwuCaR2RUN7V7QqhywjrLEpe6hBvlc8Ydz5UqnRFgriZj8nYNQnHda2oUYIsgXAXCVSBc6BXnY3KAGG1KoRZ2ONG0V8UwtAojbJ4xlxoPFnbmYw29DKZcnwkPbETrMXm9RriAsYMOkbJ2zWpZpAyMN5YyCQ097hHfNIW5TVymakzkVl_YepbtK3X1NehzyzjNeQw12R-9phj-D8t_vC6yzaf_VesV2Z0fTovPRyefnpE7fXfHZaLnZNS1K_cCiFOnXw6j5ReoQhgt |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Dynamical+Assessment+of+Inflammatory+Biomarkers+in+Predicting+the+Outcome+of+Septic+Patients+and+the+Response+to+Antimicrobial+Therapy&rft.jtitle=Journal+of+critical+care+medicine+%28Universitatea+de+Medicina+si+Farmacie+din+Targu-Mures%29&rft.au=Orfanu%2C+Alina&rft.au=Aram%C4%83%2C+Victoria&rft.au=Popescu%2C+Cristina&rft.au=Tili%C5%9Fcan%2C+C%C4%83t%C4%83lin&rft.date=2020-01-01&rft.issn=2393-1809&rft.volume=6&rft.issue=1&rft.spage=25&rft.epage=31&rft_id=info:doi/10.2478%2Fjccm-2020-0004&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2393-1809&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2393-1809&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2393-1809&client=summon |