The Dynamical Assessment of Inflammatory Biomarkers in Predicting the Outcome of Septic Patients and the Response to Antimicrobial Therapy

• Published in: Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) Vol. 6; no. 1; pp. 25 - 31
• Main Authors: Orfanu, Alina, Aramă, Victoria, Popescu, Cristina, Tilişcan, Cătălin, Streinu-Cercel, Adrian, Aramă, Ştefan Sorin
• Format: Journal Article
• Language: English
• Published: Poland Sciendo 01.01.2020
• Subjects: biomarkers of inflammation; kinetic patterns; prognosis; sepsis; therapy response; biomarkers of inflammation; kinetic patterns; prognosis; therapy response; sepsis
• ISSN: 2393-1809; 2393-1817; 2393-1817
• DOI: 10.2478/jccm-2020-0004

To evaluate the kinetics of inflammatory biomarkers in septic patients in order to identify the most reliable predictor of unfavorable outcome. A prospective analysis of septic patients was performed. Median levels of neutrophil/lymphocyte count ratio, fibrinogen, C-reactive protein and procalcitonin were dynamically assessed and comparatively analyzed. Seventy-seven patients were included. Descendent kinetic patterns were registered for all biomarkers, except C-reactive protein. At 24 hours, neutrophil/lymphocyte count ratio significantly decreased in 42.85% of cases, procalcitonin in 37.33%, C-reactive protein in 16.12% and fibrinogen in 1.58% of cases. At 72 hours, procalcitonin decreased to one-half in 70% of cases and neutrophil/lymphocyte count ratio in 67.53% of cases. Neutrophil/lymphocyte count ratio and procalcitonin significantly decreased in the first 72 hours, while C-reactive protein increased in the first 24 hours. The proportions of patients with major decrease of baseline values were higher for neutrophil/lymphocyte count ratio and procalcitonin.