Polyphenols’ Impact on Selected Biomarkers of Brain Aging in Healthy Middle-Aged and Elderly Subjects: A Review of Clinical Trials

With a constantly growing elderly population, incidences of neurodegenerative diseases are also rising and are expected to further increase over the next years, while costing health systems across the world trillions of dollars. Therefore, biomarkers to detect manifestations of brain aging early and...

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Published inNutrients Vol. 15; no. 17; p. 3770
Main Authors Ziegler, Tobias, Tsiountsioura, Melina, Meixner-Goetz, Lisa, Cvirn, Gerhard, Lamprecht, Manfred
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 29.08.2023
MDPI
Subjects
Aged
Aging
Alzheimer's disease
Amyloid beta-Peptides
antioxidants
Biological markers
Biomarkers
Blood
Brain
Brain - diagnostic imaging
Brain-Derived Neurotrophic Factor
Clinical trials
cognition
elderly
hematologic tests
Humans
Kinases
magnetism
Medical examination
Middle Aged
Nerve Growth Factor
Nervous system diseases
Older people
Polyphenols
positron-emission tomography
Proteins
Review
amyloid-beta
Aβ
polyphenols
BDNF
brain aging
tau
NGF
flavonoids
resveratrol
curcumin
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Summary:With a constantly growing elderly population, incidences of neurodegenerative diseases are also rising and are expected to further increase over the next years, while costing health systems across the world trillions of dollars. Therefore, biomarkers to detect manifestations of brain aging early and interventions to slow down its pace are of great interest. In the last years, the importance of the neurotrophins brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in the context of cognitive function and the aging brain has increased, besides the already well-established amyloid-beta (Aβ) and tau plaques. Due to their wide range of beneficial health effects as well as their antioxidant and anti-inflammatory properties, a class of secondary plant-metabolites, the so-called polyphenols, gained increasing attention. In this review, we discuss the roles of BDNF, Aβ, NGF, and tau proteins as biomarkers of brain aging and the effect of dietary polyphenol interventions on these biomarkers, assessed via blood analysis, magnetic resonance imaging (MRI), and positron emission tomography (PET).
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ISSN:2072-6643
2072-6643
DOI:10.3390/nu15173770