STRUCTURAL STUDIES ON AVIDINORUBICIN, A NOVEL ANTHRACYCLINE WITH PLATELET AGGREGATION INHIBITORY ACTIVITY

Avidinorubicin (MW 1, 214, C60H86N4O22) was isolated from the cultured broth of strain NR0576 (which was identified as Streptomyces avidinii STAPLEY et al.) by butyl alcohol extraction, Sephadex LH-20 column chromatography and preparative HPLC. Avidinorubicin inhibited thrombin-induced platelet aggr...

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Bibliographic Details
Published inJournal of antibiotics Vol. 44; no. 6; pp. 635 - 645
Main Authors AOKI, MASAHIRO, SHIRAI, HARUYOSHI, NAKAYAMA, NOBORU, ITEZONO, YOSHIKO, MORI, MITSUKO, SATOH, TOMOKO, OHSHIMA, SHOICHI, WATANABE, JUNKO, YOKOSE, KAZUTERU, SETO, HARUO
Format Journal Article
LanguageEnglish
Published Japan JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1991
Subjects
Anthracyclines
Antibiotics, Antineoplastic - biosynthesis
Antibiotics, Antineoplastic - chemistry
Antibiotics, Antineoplastic - isolation & purification
Antibiotics, Antineoplastic - pharmacology
Chromatography, Gel
Chromatography, High Pressure Liquid
Chromatography, Thin Layer
Fermentation
Humans
Hydrolysis
Magnetic Resonance Spectroscopy
Mass Spectrometry
Molecular Structure
Molecular Weight
Platelet Aggregation Inhibitors
Soil Microbiology
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Streptomyces - classification
Streptomyces - metabolism
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Summary:Avidinorubicin (MW 1, 214, C60H86N4O22) was isolated from the cultured broth of strain NR0576 (which was identified as Streptomyces avidinii STAPLEY et al.) by butyl alcohol extraction, Sephadex LH-20 column chromatography and preparative HPLC. Avidinorubicin inhibited thrombin-induced platelet aggregation with an IC50 being 7.9 μM and was determined to be a novel anthracycline possessing two units of a new aminosugar, avidinosamine, in place of two decilonitrose groups in decilorubicin.
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ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.44.635