Factors influencing survival rate in adenoid cystic carcinoma of the salivary glands

• Published in: International journal of oral and maxillofacial surgery Vol. 26; no. 6; pp. 435 - 439
• Main Authors: Huang, Minxian, Ma, Daquan, Sun, Kaihua, Yu, Guangyan, Guo, Chuanbin, Gao, Feng
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 01.12.1997; Elsevier
• Subjects: Adenoid cystic carcinoma; Adult; Biological and medical sciences; Carcinoma, Adenoid Cystic - classification; Carcinoma, Adenoid Cystic - pathology; Carcinoma, Adenoid Cystic - secondary; Carcinoma, Adenoid Cystic - surgery; Dentistry; Female; Follow-Up Studies; Humans; Linear Models; Lymphatic Metastasis - pathology; Male; Maxillary Sinus Neoplasms - pathology; Maxillary Sinus Neoplasms - surgery; Medical sciences; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local - pathology; Neoplasm Staging; Otorhinolaryngology. Stomatology; Palatal Neoplasms - pathology; Palatal Neoplasms - surgery; Parotid Neoplasms - pathology; Parotid Neoplasms - surgery; Prognosis; Proportional Hazards Models; Salivary Gland Neoplasms - pathology; Salivary Gland Neoplasms - surgery; salivary glands; Salivary Glands - innervation; Submandibular Gland Neoplasms - pathology; Submandibular Gland Neoplasms - surgery; Survival Analysis; Survival Rate; Tongue Neoplasms - pathology; Tongue Neoplasms - surgery; Tumors; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology; survival rate; salivary glands; Adenoid cystic carcinoma; Human; Salivary gland disease; Prognosis; Stomatology; Salivary gland; Malignant tumor; Predictive factor; Survival; Retrospective
• ISSN: 0901-5027; 1399-0020
• DOI: 10.1016/S0901-5027(97)80008-2

Ninety-one cases of adenoid cystic carcinoma (ACC) of the salivary glands with more than ten years' follow up were studied to investigate factors influencing the survival rate of patients, which vary according to site, histological type, clinical stage and nature of therapy. The data were statistically analysed for survival curves. Log rank tests were employed to assess the statistical significance of various groups. As a result, it may be concluded that tumour site, clinical stage and histological type are the important factors influencing the prognosis. ACC of the palate and parotid, early clinical stage, glandular/tubular histological type, and tumour without nerve involvement had the best prognosis. ACC in the submandibular gland, maxillary antrum and tongue, advanced clinical stage (stage III and IV), solid histological type, and tumour with nerve involvement had a poor prognosis.