Maternal viral infection during pregnancy elicits anti-social behavior in neonatal piglet offspring independent of postnatal microglial cell activation

• Published in: Brain, behavior, and immunity Vol. 59; pp. 300 - 312
• Main Authors: Antonson, Adrienne M, Radlowski, Emily C, Lawson, Marcus A, Rytych, Jennifer L, Johnson, Rodney W
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.01.2017
• Subjects: Allergy and Immunology; Animals; Antisocial Personality Disorder - psychology; Cytokines; Cytokines - blood; Female; Genes, MHC Class II - genetics; Lipopolysaccharides - pharmacology; Macrophage Activation; Maternal immune activation; Memory; Microglia; Microglia - immunology; Piglet; Porcine Reproductive and Respiratory Syndrome - immunology; Porcine Reproductive and Respiratory Syndrome - psychology; Porcine Reproductive and Respiratory Syndrome - virology; Porcine respiratory and reproductive syndrome virus; Pregnancy; Pregnancy Complications, Infectious; Prenatal; Prenatal Exposure Delayed Effects - psychology; Psychiatry; Social Behavior; Spatial Learning - drug effects; Sus scrofa; Swine; Prenatal; Maternal immune activation; Social behavior; Cytokines; Piglet; Microglia
• ISSN: 0889-1591; 1090-2139
• DOI: 10.1016/j.bbi.2016.09.019

Highlights • Maternal infection did not induce aberrant microglia activity in offspring. • Maternal infection did not alter offspring response to in vivo LPS challenge. • Neonatal spatial learning and memory was not impaired due to maternal infection. • Maternal infection altered social behavior in offspring postnatally.