Evaluation of immune response to orally administered Sterne strain 34F2 anthrax vaccine

• Published in: Vaccine Vol. 25; no. 29; pp. 5374 - 5377
• Main Authors: Shakya, Krishna P, Hugh-Jones, Martin E, Elzer, Philip H
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 20.07.2007; Elsevier; Elsevier Limited
• Subjects: Administration, Oral; Allergy and Immunology; Animals; Anthrax; Anthrax - prevention & control; Anthrax Vaccines - administration & dosage; Anthrax Vaccines - immunology; Antibodies, Bacterial - blood; Antigens, Bacterial - immunology; Applied microbiology; Bacillus anthracis; Bacillus anthracis - immunology; Bacterial Toxins - immunology; Bacterial Vaccines - administration & dosage; Bacterial Vaccines - immunology; Biological and medical sciences; Enzyme-Linked Immunosorbent Assay; Feeds; Female; Fundamental and applied biological sciences. Psychology; Goats; Immune response; Immunoglobulin G - blood; Microbiology; Models, Animal; Molecular weight; Oral vaccine; Rural areas; Sterne strain 34F2; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Wildlife; Wildlife conservation; Bacillus anthracis; Oral vaccine; Sterne strain 34F2; Anthrax; Infection; Immune response; Bacillales; Vaccine strain; Bacteriosis; Bacteria; Vaccine; Bacillaceae
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2007.05.003

Abstract Present animal vaccines against Bacillus anthracis infection are capable of inducing protective immunity. However, due to the route of administration, the vaccine has limited or no use in wildlife especially in rural areas of the world. Hence, an oral vaccine is needed for controlling this disease. For proof of concept we used the commercially available Sterne strain 34F2 vaccine mixed with oral scarifying agents. Although the immunological response as measured by ELISA in this group was not equal to the parenterally inoculated animals, the results indicate that the oral administration of this vaccine with oropharyngeal mucosa scarifying agents mixed with feed can induce immune responses in goats.