DNA methylation of ESR-1 and N-33 in colorectal mucosa of patients with ulcerative colitis (UC)

Epigenetic marking such as DNA methylation influence gene transcription and chromosomal stability and may also be affected by environmental exposures. Few studies exist on alteration in DNA methylation profiles (genomic and gene specific methylation) in patients with Ulcerative Colitis (UC) and none...

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Bibliographic Details
Published inEpigenetics Vol. 5; no. 5; pp. 422 - 426
Main Authors Arasaradnam, Ramesh P., Khoo, Kevin, Bradburn, Mike, Mathers, Josh, Kelly, Seamus
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 01.07.2010
Subjects
Binding
Biology
Bioscience
Calcium
Cancer
Case-Control Studies
Cell
Cell Transformation, Neoplastic - genetics
Cell Transformation, Neoplastic - metabolism
Colitis, Ulcerative - genetics
Colitis, Ulcerative - metabolism
Colon - metabolism
Colorectal Neoplasms - genetics
Cycle
DNA Methylation
Epigenomics
Estrogen Receptor alpha - genetics
Estrogen Receptor alpha - metabolism
Female
Humans
Intestinal Mucosa - metabolism
Landes
Male
Membrane Proteins - genetics
Membrane Proteins - metabolism
Middle Aged
Organogenesis
Promoter Regions, Genetic
Proteins
Rectum - metabolism
Tumor Suppressor Proteins - genetics
Tumor Suppressor Proteins - metabolism
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Summary:Epigenetic marking such as DNA methylation influence gene transcription and chromosomal stability and may also be affected by environmental exposures. Few studies exist on alteration in DNA methylation profiles (genomic and gene specific methylation) in patients with Ulcerative Colitis (UC) and none assessing its relationship with lifestyle exposures.
ISSN:1559-2294
1559-2308
DOI:10.4161/epi.5.5.11959