Genotype distribution of norovirus around the emergence of Sydney_2012 and the antigenic drift of contemporary GII.4 epidemic strains

• Published in: Journal of clinical virology Vol. 72; pp. 95 - 101
• Main Authors: Zhang, Jun, Shen, Zhen, Zhu, Zhaoqin, Zhang, Wanju, Chen, Huifen, Qian, Fangxing, Chen, Haili, Wang, Gang, Wang, Moying, Hu, Yunwen, Yuan, Zhenghong
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2015
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Allergy and Immunology; Antibodies, Viral - immunology; Antigenic variation; Antigens, Viral - immunology; Antigens, Viral - metabolism; Caliciviridae Infections - epidemiology; Caliciviridae Infections - virology; China - epidemiology; Epidemics; Female; Genetic Drift; Genotype; GII.4 norovirus; Humans; Infectious Disease; Male; Middle Aged; Molecular Epidemiology; Norovirus; Norovirus - classification; Norovirus - genetics; Norovirus - immunology; Norovirus - isolation & purification; Protein Binding; Receptor switch; Receptors, Virus - metabolism; Sydney_2012; Viral Structural Proteins - immunology; Viral Structural Proteins - metabolism; Young Adult; China, People's Rep., Shanghai; Sydney_2012; GII.4 norovirus; open reading frames; histo-blood group antigen; Receptor switch; NoV; norovirus; ORFs; HBGA; VP1; Antigenic variation; viral protein 1; Molecular epidemiology
• ISSN: 1386-6532; 1873-5967
• DOI: 10.1016/j.jcv.2015.09.009

Highlights • Sydeny_2012 has completely replaced Den_Haag_2006b and New_Orleans_2009 since its emergence in Shanghai in October 2012. • The contemporary GII.4 epidemic norovirus strains displayed commonly high tropism to the histo-blood group antigen receptors. • Sydeny_2012 was antigenically different from Den_Haag_2006b and New_Orleans_2009. • The contemporary GII.4 strains were evolving via epochal evolution without altered ligand binding profiles.