Divergent reaction mechanisms in the aminofluorination of alkenes

The aminofluorination of alkenes has become an attractive platform for the synthesis of β-amino-fluorinated compounds, valuable building blocks in medicinal and agricultural chemistry. The novel methodologies disclosed in recent years have unraveled a broad array of reaction mechanisms, so that the...

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Bibliographic Details
Published inChimia Vol. 68; no. 6; p. 430
Main Authors Kong, Wangqing, Merino, Estíbaliz, Nevado, Cristina
Format Journal Article
LanguageEnglish
German
Published Switzerland Swiss Chemical Society 01.01.2014
Subjects
Alkenes
Aminofluorination
Difunctionalization
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Summary:The aminofluorination of alkenes has become an attractive platform for the synthesis of β-amino-fluorinated compounds, valuable building blocks in medicinal and agricultural chemistry. The novel methodologies disclosed in recent years have unraveled a broad array of reaction mechanisms, so that the interest in these transformations transcends the mere synthetic aspects. This review aims to summarize the most relevant findings in this area attending at the nature of the fluorine source, and thus the specific mechanism operating in each of these transformations, namely electrophilic, nucleophilic, radical, and late transition metal-catalyzed reactions.
ISSN:0009-4293
2673-2424
DOI:10.2533/chimia.2014.430