Antipyretic,anti-inflammatory and analgesic properties of nilavembu kudineer choornam:a classical preparation used in the treatment of chikungunya fever

• Published in: Asian Pacific journal of tropical medicine Vol. 4; no. 10; pp. 819 - 823
• Main Authors: Anbarasu, K, Manisenthil, Kumar KT, Ramachandran, S
• Format: Journal Article
• Language: English
• Published: India Elsevier B.V 01.10.2011; Government Hospital, Krishnarayapuram, Karur-639 102, Tamil Nadu, India%Department of Pharmacology, KMCH College of Pharmacy, Coimbatore-641 048, Tamil Nadu, India
• Subjects: Acetic Acid; Analgesic; Animals; Anti-inflammatory; Antipyretic; Carrageenan; Case-Control Studies; Chikungunya; Chikungunya fever; Disease Models, Animal; Dose-Response Relationship, Drug; Female; fever; Fever - chemically induced; Fever - drug therapy; Food; Hindlimb; India; Inflammation - chemically induced; Inflammation - drug therapy; Male; Medicine, Traditional - methods; Mice; Pain - chemically induced; Pain - drug therapy; Pain Measurement - drug effects; Phytotherapy; Plants, Medicinal; Rats; Rats, Wistar; Saccharomyces cerevisiae; Treatment Outcome; India; Antipyretic; Analgesic; Chikungunya fever; Anti-inflammatory
• ISSN: 1995-7645; 2352-4146
• DOI: 10.1016/S1995-7645(11)60201-0

<正>Objective:To investigate the efficacy of ethanolic extract of nilavembu kudineer choornam (EENKC) in inflammation,pain and fever using animal models to support its actions.Methods: Acute toxicity study of EENKC was performed in mice to fix the effective dose.The antipyretic, anti-inflammatory and analgesic activity of EENKC was evaluated in brewer’s yeast induced pyrexia in rats,carrageenan-induced inflammation in rats and acetic-acid induced writhing in mice model.Results:Acute toxicity revealed that EENKC didn’t show death and toxic signs up to 2 000 mg/kg.In brewer’s yeast induced pyrexia and carrageenan-induced inflammation EENKC at the doses of 200 and 400 mg/kg inhibited fever and inflammation significantly(P<0.01 and<0.05) compared to control animals.In mice,the number of writhing induced by acetic-acid was significantly(P<0.01) reduced after treatment with both the dose of EENKC than control animals. EENKC 200 mg/kg inhibits inflammation higher level in carrageenan-induced paw edema,but there is no significant difference when compared to indomethacin 10 mg/kg.Conclusions:The present findings revealed that EENKC possesses antipyretic,anti-inflammatory and analgesic activity which supports nilavembu kudineer choornam efficacy in chikungunya fever.