Antipyretic,anti-inflammatory and analgesic properties of nilavembu kudineer choornam:a classical preparation used in the treatment of chikungunya fever
<正>Objective:To investigate the efficacy of ethanolic extract of nilavembu kudineer choornam (EENKC) in inflammation,pain and fever using animal models to support its actions.Methods: Acute toxicity study of EENKC was performed in mice to fix the effective dose.The antipyretic, anti-in...
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Published in | Asian Pacific journal of tropical medicine Vol. 4; no. 10; pp. 819 - 823 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
India
Elsevier B.V
01.10.2011
Government Hospital, Krishnarayapuram, Karur-639 102, Tamil Nadu, India%Department of Pharmacology, KMCH College of Pharmacy, Coimbatore-641 048, Tamil Nadu, India |
Subjects | |
Online Access | Get full text |
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Summary: | <正>Objective:To investigate the efficacy of ethanolic extract of nilavembu kudineer choornam (EENKC) in inflammation,pain and fever using animal models to support its actions.Methods: Acute toxicity study of EENKC was performed in mice to fix the effective dose.The antipyretic, anti-inflammatory and analgesic activity of EENKC was evaluated in brewer’s yeast induced pyrexia in rats,carrageenan-induced inflammation in rats and acetic-acid induced writhing in mice model.Results:Acute toxicity revealed that EENKC didn’t show death and toxic signs up to 2 000 mg/kg.In brewer’s yeast induced pyrexia and carrageenan-induced inflammation EENKC at the doses of 200 and 400 mg/kg inhibited fever and inflammation significantly(P<0.01 and<0.05) compared to control animals.In mice,the number of writhing induced by acetic-acid was significantly(P<0.01) reduced after treatment with both the dose of EENKC than control animals. EENKC 200 mg/kg inhibits inflammation higher level in carrageenan-induced paw edema,but there is no significant difference when compared to indomethacin 10 mg/kg.Conclusions:The present findings revealed that EENKC possesses antipyretic,anti-inflammatory and analgesic activity which supports nilavembu kudineer choornam efficacy in chikungunya fever. |
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Bibliography: | Anbarasu K~1,Manisenthil Kumar KT~2,Ramachandran S~(2*) 1 Government Hospital,Krishnarayapuram,Karur-639 102,Tamil Nadu,India 2 Department of Pharmacology;KMCH College of Pharmacy,Coimbatore-641048,Tamil Nadu,India ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1995-7645 2352-4146 |
DOI: | 10.1016/S1995-7645(11)60201-0 |