Comparative analysis of restraint stress-induced depressive-like phenotypes in C57BL/6N mice derived from three different sources

• Published in: Laboratory animal research Vol. 36; no. 1; pp. 1 - 9
• Main Authors: Hwang, Dong-Joo, Kwon, Ki-Chun, Hwang, Dae-Youn, Seo, Min-Soo, Kim, Kil-Soo, Jung, Young-Suk, Cho, Joon-Yong
• Format: Journal Article
• Language: English
• Published: Seole BioMed Central 26.08.2020; BMC; 한국실험동물학회
• Subjects: Antibodies; Anxiety; Behavior; Body weight; C57BL/6NKorl mice; Comparative analysis; Depressive disorder; Etiology; Laboratory animals; Mental depression; Mental disorders; Oxidative stress; Pharmacovigilance; Phenotypes; Reagents; Restraint stress; Stress; 수의학; United States > US; Japan; Finland
• ISSN: 2233-7660; 1738-6055; 2233-7660
• DOI: 10.1186/s42826-020-00062-0

C57BL/6NKorl mice are a novel mouse stock recently developed by the National Institute of Food and Drug Safety Evaluation in Korea. Extensive research into the nature of C57BL/6NKorl mice is being conducted. However, there is no scientific evidence for the phenotypic response to restraint stress (RST), a stress paradigm for modeling depressive disorders, in rodents. In this study, we investigated the repeated RST-induced depressive-like phenotypes in C57BL/6 N mouse substrains (viz., C57BL/6NKorl mice from Korea, C57BL/6NA mice from the United States, and C57BL/6NB mice from Japan) obtained from different sources. The results showed that C57BL/6 N mice derived from various sources exposed to repeated RST resulted in depressive-like phenotypes reflected by a similar degree of behavioral modification and susceptibility to oxidative stress in a duration-dependent manner, except for the distinctive features (increased body weight (BW) and tolerance to the suppression of BW gain by exposure to repeated RST) in C57BL/6NKorl mice. Taken together, the duration-dependent alteration in depressive-like phenotypes by repeated exposure to RST observed in this study may provide valuable insights into the nature of C57BL/6NKorl mice as an alternative animal resource for better understanding of the etiology of depressive disorders and the mechanisms of antidepressant actions.