Long noncoding RNA NEAT1 promotes cell proliferation and invasion by regulating hnRNP A2 expression in hepatocellular carcinoma cells

• Published in: OncoTargets and therapy Vol. 10; pp. 1003 - 1016
• Main Authors: Mang, Yuanyi, Li, Li, Ran, Jianghua, Zhang, Shengning, Liu, Jing, Li, Laibang, Chen, Yiming, Liu, Jian, Gao, Yang, Ren, Gang
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2017; Taylor & Francis Ltd; Dove Medical Press
• Subjects: Binding proteins; Biomarkers; Cell growth; Development and progression; Gene expression; Genetic aspects; Health aspects; Hepatocellular carcinoma; Hepatology; Hospitals; Liver cancer; Original Research; Physiological aspects; Proteins; Regulatory genes; RNA; Tumorigenesis; United States > US; China; long noncoding RNA; HCC; RNA-binding protein; NEAT1
• ISSN: 1178-6930; 1178-6930
• DOI: 10.2147/OTT.S116319

Growing evidence demonstrates that long noncoding RNAs (lncRNAs) are involved in the progression of various cancers, including hepatocellular carcinoma (HCC). The role of nuclear-enriched abundant transcript 1 ( ), an essential lncRNA for the formation of nuclear body paraspeckles, has not been fully explored in HCC. We aimed to determine the expression, roles and functional mechanisms of in the proliferation and invasion of HCC. Based on real-time polymerase chain reaction data, we suggest that is upregulated in HCC tissues compared with noncancerous liver tissues. The knockdown of altered global gene expression patterns and reduced HCC cell proliferation, invasion and migration. RNA immunoprecipitation and RNA pull-down assays confirmed that U2AF65 binds to . Furthermore, the study indicated that regulated expression and that this regulation may be associated with the -U2AF65 protein complex. Thus, the regulation mechanism promotes HCC pathogenesis and may provide a potential target for the prognosis and treatment of HCC.