Bioinspired neuron-like electronics
As an important application of functional biomaterials, neural probes have contributed substantially to studying the brain. Bioinspired and biomimetic strategies have begun to be applied to the development of neural probes, although these and previous generations of probes have had structural and me...
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Published in | Nature materials Vol. 18; no. 5; pp. 510 - 517 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
01.05.2019
Nature Publishing Group |
Subjects | |
Online Access | Get full text |
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Summary: | As an important application of functional biomaterials, neural probes have contributed substantially to studying the brain. Bioinspired and biomimetic strategies have begun to be applied to the development of neural probes, although these and previous generations of probes have had structural and mechanical dissimilarities from their neuron targets that lead to neuronal loss, neuroinflammatory responses and measurement instabilities. Here, we present a bioinspired design for neural probes—neuron-like electronics (NeuE)—where the key building blocks mimic the subcellular structural features and mechanical properties of neurons. Full three-dimensional mapping of implanted NeuE–brain interfaces highlights the structural indistinguishability and intimate interpenetration of NeuE and neurons. Time-dependent histology and electrophysiology studies further reveal a structurally and functionally stable interface with the neuronal and glial networks shortly following implantation, thus opening opportunities for next-generation brain–machine interfaces. Finally, the NeuE subcellular structural features are shown to facilitate migration of endogenous neural progenitor cells, thus holding promise as an electrically active platform for transplantation-free regenerative medicine.
Neural probes mimicking the size and mechanical properties of neurons interpenetrate the brain tissue, allowing stable single-unit recordings from implantation up to at least three months, and acting as scaffolds for the migration of new-born neurons. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 X.Y. and C.M.L. designed the experiments. X.Y., T.Z., T.J.Z., G.H., Y.Z., R.D.V., T.-M.F. and T.G. performed the experiments. X.Y., T.Z., T.J.Z. and C.M.L. analyzed the data. X.Y. and C.M.L. wrote the paper. All authors discussed the results, revised or commented on the manuscript. These authors contributed equally to this work. Author contributions |
ISSN: | 1476-1122 1476-4660 |
DOI: | 10.1038/s41563-019-0292-9 |