Phellinstatin, a new inhibitor of enoyl-ACP reductase produced by the medicinal fungus Phellinus linteus

• Published in: Bioorganic & medicinal chemistry letters Vol. 21; no. 6; pp. 1716 - 1718
• Main Authors: Cho, Jun-Young, Kwon, Yun-Ju, Sohn, Mi-Jin, Seok, Soon-Ja, Kim, Won-Gon
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 15.03.2011; Elsevier
• Subjects: Antibacterial; antibacterial properties; Biological and medical sciences; Catechols - pharmacology; chemistry; culture media; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Enoyl-ACP reductase; Enzyme Inhibitors - pharmacology; Fungi - enzymology; General pharmacology; Hispidin; Inhibitor; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Medical sciences; medicinal fungi; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phellinus linteus; Pyrones - pharmacology; spectral analysis; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Staphylococcus aureus; Asia; Korea; Phellinus linteus; Enoyl-ACP reductase; Inhibitor; Antibacterial; Hispidin; Staphylococcus aureus; Trimer; Enzyme; Pharmacognosy; Lactone; Enoyl-[acyl-carrier-protein] reductase (NADH); Biological activity; Basidiomycota; Fungi; Folk medicine; Bacteria; Micrococcales; Isolation; Micrococcaceae; Oxidoreductases; Antibacterial agent; Structural analysis
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/j.bmcl.2011.01.080

A new trimeric hispidin derivative, phellinstatin, was isolated from a culture broth of the medicinal fungus Phellinus linteus and its structure was established by various spectral analysis. Phellinstatin strongly inhibited Staphylococcus aureus enoyl-ACP reductase with an IC 50 of 6 M and also showed antibacterial activity against S. aureus and MRSA. A new trimeric hispidin derivative, phellinstatin, was isolated from a culture broth of the medicinal fungus Phellinus linteus and its structure was established by various spectral analysis. Phellinstatin strongly inhibited Staphylococcus aureus enoyl-ACP reductase with an IC 50 of 6 μM and also showed antibacterial activity against S. aureus and MRSA.