Effect of calcium citrate on bone integration in a rabbit femur defect model
<正>Objective:To explore effect of calcium citrate on bone integration in a rabbit femur defect model, and to compare the bone formation with different sizes by radiological and histological study. Methods:Twenty-four male Japanese white rabbits were randomly divided into three groups (...
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| Abstract | <正>Objective:To explore effect of calcium citrate on bone integration in a rabbit femur defect model, and to compare the bone formation with different sizes by radiological and histological study. Methods:Twenty-four male Japanese white rabbits were randomly divided into three groups (Group A.B.C)in this study.Under anesthesia,defects of four sizes(1.2,1.5,2.0 and 2.5 mm) were created in each of the rabbits.Commercially pure calcium citrate powder was placed inside the medullary compartment of the femur(Experimental),while in the contralateral femur(Control) nothing was implanted.The defects were analyzed using radiography and histological analysis by using Imagepro-Plus 6.0 software after animal was sacrificed at 4th(Group A),6th(Group B) and 8th(Group C) weeks postoperatively.Four samples were analyzed for each size of defect and each healing period.Results:The histological and the radiologic evaluation were performed after sacrification of all rabbits on postoperative 4th and 6th weeks,It showed significant difference between the experimental group and the control group when these defects were less than or equal to 2.0 mm.No statistical difference was observed when these defects were larger than 2.0 mm at all healing periods except at the 4th week.Conclusions:Calcium citrate affects the early periods of hone defects healing mechanism in Japanese white rabbits positively,especially when the defect is not too large,We suggest further studies on calcium citrate to determine the effects of various dosages,administration ways and the experimental time on the bone defects. |
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| AbstractList | To explore effect of calcium citrate on bone integration in a rabbit femur defect model, and to compare the bone formation with different sizes by radiological and histological study.
Twenty-four male Japanese white rabbits were randomly divided into three groups (Group A, B, C) in this study. Under anesthesia, defects of four sizes (1.2, 1.5, 2.0 and 2.5 mm) were created in each of the rabbits. Commercially pure calcium citrate powder was placed inside the medullary compartment of the femur (Experimental), while in the contralateral femur (Control) nothing was implanted. The defects were analyzed using radiography and histological analysis by using Imagepro-Plus 6.0 software after animal was sacrificed at 4th(Group A), 6th(Group B) and 8th(Group C) weeks postoperatively. Four samples were analyzed for each size of defect and each healing period.
The histological and the radiologic evaluation were performed after sacrification of all rabbits on postoperative 4th and 6th weeks, It showed significant difference between the experimental group and the control group when these defects were less than or equal to 2.0 mm. No statistical difference was observed when these defects were larger than 2.0 mm at all healing periods except at the 4th week.
Calcium citrate affects the early periods of bone defects healing mechanism in Japanese white rabbits positively, especially when the defect is not too large. We suggest further studies on calcium citrate to determine the effects of various dosages, administration ways and the experimental time on the bone defects. <正>Objective:To explore effect of calcium citrate on bone integration in a rabbit femur defect model, and to compare the bone formation with different sizes by radiological and histological study. Methods:Twenty-four male Japanese white rabbits were randomly divided into three groups (Group A.B.C)in this study.Under anesthesia,defects of four sizes(1.2,1.5,2.0 and 2.5 mm) were created in each of the rabbits.Commercially pure calcium citrate powder was placed inside the medullary compartment of the femur(Experimental),while in the contralateral femur(Control) nothing was implanted.The defects were analyzed using radiography and histological analysis by using Imagepro-Plus 6.0 software after animal was sacrificed at 4th(Group A),6th(Group B) and 8th(Group C) weeks postoperatively.Four samples were analyzed for each size of defect and each healing period.Results:The histological and the radiologic evaluation were performed after sacrification of all rabbits on postoperative 4th and 6th weeks,It showed significant difference between the experimental group and the control group when these defects were less than or equal to 2.0 mm.No statistical difference was observed when these defects were larger than 2.0 mm at all healing periods except at the 4th week.Conclusions:Calcium citrate affects the early periods of hone defects healing mechanism in Japanese white rabbits positively,especially when the defect is not too large,We suggest further studies on calcium citrate to determine the effects of various dosages,administration ways and the experimental time on the bone defects. ABSTRACT Objective:To explore effect of calcium citrate on bone integration in a rabbit femur defect model, and to compare the bone formation with different sizes by radiological and histological study. Methods:Twenty-four male Japanese white rabbits were randomly divided into three groups (GroupA, B, C) in this study. Under anesthesia, defects of four sizes (1.2, 1.5, 2.0 and2.5 mm) were created in each of the rabbits. Commercially pure calcium citrate powder was placed inside the medullary compartment of the femur (Experimental), while in the contralateral femur (Control) nothing was implanted. The defects were analyzed using radiography and histological analysis by using Imagepro-Plus6.0 software after animal was sacrificed at 4th(GroupA), 6th(GroupB) and8th(GroupC) weeks postoperatively. Four samples were analyzed for each size of defect and each healing period.Results:The histological and the radiologic evaluation were performed after sacrification of all rabbits on postoperative4th and6th weeks, It showed significant difference between the experimental group and the control group when these defects were less than or equal to2.0 mm. No statistical difference was observed when these defects were larger than2.0 mm at all healing periods except at the4th week.Conclusions: Calcium citrate affects the early periods of bone defects healing mechanism in Japanese white rabbits positively, especially when the defect is not too large. We suggest further studies on calcium citrate to determine the effects of various dosages, administration ways and the experimental time on the bone defects. Objective: To explore effect of calcium citrate on bone integration in a rabbit femur defect model, and to compare the bone formation with different sizes by radiological and histological study. Methods: Twenty-four male Japanese white rabbits were randomly divided into three groups (Group A, B, C) in this study. Under anesthesia, defects of four sizes (1.2, 1.5, 2.0 and 2.5 mm) were created in each of the rabbits. Commercially pure calcium citrate powder was placed inside the medullary compartment of the femur (Experimental), while in the contralateral femur (Control) nothing was implanted. The defects were analyzed using radiography and histological analysis by using Imagepro-Plus 6.0 software after animal was sacrificed at 4th(Group A), 6th(Group B) and 8th(Group C) weeks postoperatively. Four samples were analyzed for each size of defect and each healing period. Results: The histological and the radiologic evaluation were performed after sacrification of all rabbits on postoperative 4th and 6th weeks, It showed significant difference between the experimental group and the control group when these defects were less than or equal to 2.0 mm. No statistical difference was observed when these defects were larger than 2.0 mm at all healing periods except at the 4th week. Conclusions: Calcium citrate affects the early periods of bone defects healing mechanism in Japanese white rabbits positively, especially when the defect is not too large. We suggest further studies on calcium citrate to determine the effects of various dosages, administration ways and the experimental time on the bone defects. To explore effect of calcium citrate on bone integration in a rabbit femur defect model, and to compare the bone formation with different sizes by radiological and histological study.OBJECTIVETo explore effect of calcium citrate on bone integration in a rabbit femur defect model, and to compare the bone formation with different sizes by radiological and histological study.Twenty-four male Japanese white rabbits were randomly divided into three groups (Group A, B, C) in this study. Under anesthesia, defects of four sizes (1.2, 1.5, 2.0 and 2.5 mm) were created in each of the rabbits. Commercially pure calcium citrate powder was placed inside the medullary compartment of the femur (Experimental), while in the contralateral femur (Control) nothing was implanted. The defects were analyzed using radiography and histological analysis by using Imagepro-Plus 6.0 software after animal was sacrificed at 4th(Group A), 6th(Group B) and 8th(Group C) weeks postoperatively. Four samples were analyzed for each size of defect and each healing period.METHODSTwenty-four male Japanese white rabbits were randomly divided into three groups (Group A, B, C) in this study. Under anesthesia, defects of four sizes (1.2, 1.5, 2.0 and 2.5 mm) were created in each of the rabbits. Commercially pure calcium citrate powder was placed inside the medullary compartment of the femur (Experimental), while in the contralateral femur (Control) nothing was implanted. The defects were analyzed using radiography and histological analysis by using Imagepro-Plus 6.0 software after animal was sacrificed at 4th(Group A), 6th(Group B) and 8th(Group C) weeks postoperatively. Four samples were analyzed for each size of defect and each healing period.The histological and the radiologic evaluation were performed after sacrification of all rabbits on postoperative 4th and 6th weeks, It showed significant difference between the experimental group and the control group when these defects were less than or equal to 2.0 mm. No statistical difference was observed when these defects were larger than 2.0 mm at all healing periods except at the 4th week.RESULTSThe histological and the radiologic evaluation were performed after sacrification of all rabbits on postoperative 4th and 6th weeks, It showed significant difference between the experimental group and the control group when these defects were less than or equal to 2.0 mm. No statistical difference was observed when these defects were larger than 2.0 mm at all healing periods except at the 4th week.Calcium citrate affects the early periods of bone defects healing mechanism in Japanese white rabbits positively, especially when the defect is not too large. We suggest further studies on calcium citrate to determine the effects of various dosages, administration ways and the experimental time on the bone defects.CONCLUSIONSCalcium citrate affects the early periods of bone defects healing mechanism in Japanese white rabbits positively, especially when the defect is not too large. We suggest further studies on calcium citrate to determine the effects of various dosages, administration ways and the experimental time on the bone defects. |
| Author | Wei Zhang Wei Wang Qing-Yu Chen Zhong-Qin Lin Shao-Wen Cheng Dong-Quan Kou Xiao-Zhou Ying Yue Shen Xiao-Jie Cheng Peng-Fei Nie Xiu-Cui Li Ferdinand An Rompis Hang Huang Hua Zhang Zhong-Lin Mu Lei Peng |
| AuthorAffiliation | Department of Orthopaedic Surgery,the Second Affiliated Hospital of Wenzhou Medical College Department of Orthopaedic Surgery,Hospital of Integrated Traditional Chinese and Western Medicine of Wenzhou Department of Respiratory Medicine,Yuying Children’s Hospital Affiliated to Wenzhou Medical College Trauma Center of the Affiliated Hospital of Hainan Medical College Haikou 120 Emergency Center International Nursing School of Hainan Medical College Graduate Department of Hainan Medical College The Second Affiliated Hospital of Wenzhou Medical College,Trauma Center of the Affiliated Hospital of Hainan Medical College |
| AuthorAffiliation_xml | – name: Department of 0rthopaedic Surgery, the Second Affiliated Hospital of Wenzhou Medical College,109 Xue Yuan Xi Road, Wenzhou 325000, China%Department of 0rthopaedic Surgery, Hospital of Integrated Traditional Chinese and Western Medicine of Wenzhou, Wenzhou, China%Department of Respiratory Medicine, Yuying Children's Hospital Affiliated to Wenzhou Medical College, Wenzhou, Zhejiang, China%Trauma Center of the Affiliated Hospital of Hainan Medical College, 31 Long Hua Road, Haikou, China%Haikou120 Emergency Center, 43 Renmin Da Dao, Haikou 570208, Hainan Province, China%International Nursing School of Hainan Medical College, 3 Xueyuan Road, Haikou 571199, Hainan Province, China%Graduate Department of Hainan Medical College, 3 Xueyuan Road, Haikou 571199, Hainan Province, China%The Second Affiliated Hospital of Wenzhou Medical College, Trauma Center of the Affiliated Hospital of Hainan Medical College, 109 Xue Yuan Xi Road, Wenzhou 325000, China |
| Author_xml | – sequence: 1 givenname: Wei surname: Zhang fullname: Zhang, Wei organization: Department of Orthopaedic Surgery, the Second Affiliated Hospital of Wenzhou Medical College,109 Xue Yuan Xi Road, Wenzhou 325000, China – sequence: 2 givenname: Wei surname: Wang fullname: Wang, Wei organization: Department of Orthopaedic Surgery, the Second Affiliated Hospital of Wenzhou Medical College,109 Xue Yuan Xi Road, Wenzhou 325000, China – sequence: 3 givenname: Qing-Yu surname: Chen fullname: Chen, Qing-Yu organization: Department of Orthopaedic Surgery, the Second Affiliated Hospital of Wenzhou Medical College,109 Xue Yuan Xi Road, Wenzhou 325000, China – sequence: 4 givenname: Zhong-Qin surname: Lin fullname: Lin, Zhong-Qin organization: Department of Orthopaedic Surgery, Hospital of Integrated Traditional Chinese and Western Medicine of Wenzhou, Wenzhou, China – sequence: 5 givenname: Shao-Wen surname: Cheng fullname: Cheng, Shao-Wen organization: Department of Orthopaedic Surgery, the Second Affiliated Hospital of Wenzhou Medical College,109 Xue Yuan Xi Road, Wenzhou 325000, China – sequence: 6 givenname: Dong-Quan surname: Kou fullname: Kou, Dong-Quan organization: Department of Orthopaedic Surgery, the Second Affiliated Hospital of Wenzhou Medical College,109 Xue Yuan Xi Road, Wenzhou 325000, China – sequence: 7 givenname: Xiao-Zhou surname: Ying fullname: Ying, Xiao-Zhou organization: Department of Orthopaedic Surgery, the Second Affiliated Hospital of Wenzhou Medical College,109 Xue Yuan Xi Road, Wenzhou 325000, China – sequence: 8 givenname: Yue surname: Shen fullname: Shen, Yue organization: Department of Orthopaedic Surgery, the Second Affiliated Hospital of Wenzhou Medical College,109 Xue Yuan Xi Road, Wenzhou 325000, China – sequence: 9 givenname: Xiao-Jie surname: Cheng fullname: Cheng, Xiao-Jie organization: Department of Orthopaedic Surgery, the Second Affiliated Hospital of Wenzhou Medical College,109 Xue Yuan Xi Road, Wenzhou 325000, China – sequence: 10 givenname: Peng-Fei surname: Nie fullname: Nie, Peng-Fei organization: Department of Orthopaedic Surgery, the Second Affiliated Hospital of Wenzhou Medical College,109 Xue Yuan Xi Road, Wenzhou 325000, China – sequence: 11 givenname: Xiu-Cui surname: Li fullname: Li, Xiu-Cui organization: Department of Respiratory Medicine, Yuying Children's Hospital Affiliated to Wenzhou Medical College, Wenzhou, Zhejiang, China – sequence: 12 givenname: Ferdinand An surname: Rompis fullname: Rompis, Ferdinand An organization: Trauma Center of the Affiliated Hospital of Hainan Medical College, 31 Long Hua Road, Haikou, China – sequence: 13 givenname: Hang surname: Huang fullname: Huang, Hang organization: Haikou120 Emergency Center, 43 Renmin Da Dao, Haikou 570208, Hainan Province, China – sequence: 14 givenname: Hua surname: Zhang fullname: Zhang, Hua email: zhanghuashelley@hotmail.com organization: International Nursing School of Hainan Medical College, 3 Xueyuan Road, Haikou 571199, Hainan Province, China – sequence: 15 givenname: Zhong-Lin surname: Mu fullname: Mu, Zhong-Lin email: muzhonglin2@sina.com organization: Graduate Department of Hainan Medical College, 3 Xueyuan Road, Haikou 571199, Hainan Province, China – sequence: 16 givenname: Lei surname: Peng fullname: Peng, Lei email: xiaobo197518@163.com organization: The Second Affiliated Hospital of Wenzhou Medical College, Trauma Center of the Affiliated Hospital of Hainan Medical College, 109 Xue Yuan Xi Road, Wenzhou 325000, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22449524$$D View this record in MEDLINE/PubMed |
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| Copyright | 2012 Hainan Medical College Copyright © 2012 Hainan Medical College. Published by Elsevier B.V. All rights reserved. Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
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| DOI | 10.1016/S1995-7645(12)60045-5 |
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| Keywords | Fracture healing Bone Experiment Calcium citrate |
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| Notes | Wei Zhang~(1△),Wei Wang~(1△),Qing-Yu Chen~1,Zhong-Qin Lin~2,Shao-Wen Cheng~1,Dong-Quan Kou~1,Xiao-Zhou Ying~1,Yue Shen~1,Xiao-Jie Cheng~1,Peng-Fei Nie~1,Xiu-Cui Li~3, Ferdinand An Rompis~4,Hang Huang~5,Hua Zhang~(6*),Zhong-Lin Mu~(7*),Lei Peng~(8*) 1 Department of Orthopaedic Surgery,the Second Affiliated Hospital of Wenzhou Medical College,109 Xue Yuan Xi Road,Wenzhou 325000,China 2 Department of Orthopaedic Surgery,Hospital of Integrated Traditional Chinese and Western Medicine of Wenzhou,Wenzhou,China 3 Department of Respiratory Medicine,Yuying Children’s Hospital Affiliated to Wenzhou Medical College,Wenzhou,Zhejiang,China 4 Trauma Center of the Affiliated Hospital of Hainan Medical College,31 Long Hua Road,Haikou,China 5 Haikou 120 Emergency Center,43 Renmin Da Dao,Haikou 570208,Hainan Province,China 6 International Nursing School of Hainan Medical College,3 Xueyuan Road,Haikou 571199,Hainan Province,China 7 Graduate Department of Hainan Medical College,3 Xueyuan Road,Haikou 571199,Hainan Province,China 8The Second Affiliated Hospital of Wenzhou Medical College,Trauma Center of the Affiliated Hospital of Hainan Medical College,109 Xue Yuan Xi Road,Wenzhou 325000,China ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
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| Publisher | Elsevier B.V Department of 0rthopaedic Surgery, the Second Affiliated Hospital of Wenzhou Medical College,109 Xue Yuan Xi Road, Wenzhou 325000, China%Department of 0rthopaedic Surgery, Hospital of Integrated Traditional Chinese and Western Medicine of Wenzhou, Wenzhou, China%Department of Respiratory Medicine, Yuying Children's Hospital Affiliated to Wenzhou Medical College, Wenzhou, Zhejiang, China%Trauma Center of the Affiliated Hospital of Hainan Medical College, 31 Long Hua Road, Haikou, China%Haikou120 Emergency Center, 43 Renmin Da Dao, Haikou 570208, Hainan Province, China%International Nursing School of Hainan Medical College, 3 Xueyuan Road, Haikou 571199, Hainan Province, China%Graduate Department of Hainan Medical College, 3 Xueyuan Road, Haikou 571199, Hainan Province, China%The Second Affiliated Hospital of Wenzhou Medical College, Trauma Center of the Affiliated Hospital of Hainan Medical College, 109 Xue Yuan Xi Road, Wenzhou 325000, China |
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| Snippet | <正>Objective:To explore effect of calcium citrate on bone integration in a rabbit femur defect model, and to compare the bone formation with different... To explore effect of calcium citrate on bone integration in a rabbit femur defect model, and to compare the bone formation with different sizes by radiological... Objective: To explore effect of calcium citrate on bone integration in a rabbit femur defect model, and to compare the bone formation with different sizes by... ABSTRACT Objective:To explore effect of calcium citrate on bone integration in a rabbit femur defect model, and to compare the bone formation with different... |
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| SubjectTerms | Animals Bone Bone Density Conservation Agents - pharmacology Bone Regeneration - drug effects Calcium Calcium citrate Calcium Citrate - pharmacology citrate Experiment Femur - diagnostic imaging Femur - drug effects Fracture Fracture healing healing Male Rabbits Radiography Random Allocation Wound Healing - drug effects |
| Title | Effect of calcium citrate on bone integration in a rabbit femur defect model |
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