New Horizon: Exercise and a Focus on Tissue-Brain Crosstalk

Abstract The world population is aging, leading to increased rates of neurodegenerative disorders. Exercise has countless health benefits and has consistently been shown to improve brain health and cognitive function. The purpose of this review is to provide an overview of exercise-induced adaptatio...

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Published inThe journal of clinical endocrinology and metabolism Vol. 106; no. 8; pp. 2147 - 2163
Main Authors Townsend, Logan K, MacPherson, Rebecca E K, Wright, David C
Format Journal Article
LanguageEnglish
Published US Oxford University Press 01.08.2021
Subjects
Brain
Cathepsin B
Cathepsins
Cognitive ability
Muscles
Nervous system diseases
Neurodegenerative diseases
Physical fitness
Physiological aspects
Type 2 diabetes
BDNF
GDF15
exercise
brain
irisin
GPLD1
FGF21
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Summary:Abstract The world population is aging, leading to increased rates of neurodegenerative disorders. Exercise has countless health benefits and has consistently been shown to improve brain health and cognitive function. The purpose of this review is to provide an overview of exercise-induced adaptations in the brain with a focus on crosstalk between peripheral tissues and the brain. We highlight recent investigations into exercise-induced circulating factors, or exerkines, including irisin, cathepsin B, GPLD1, and ketones and the mechanisms mediating their effects in the brain.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0021-972X
1945-7197
DOI:10.1210/clinem/dgab333