Reversal of the late asthmatic response increases exhaled nitric oxide

• Published in: Respiratory medicine Vol. 99; no. 12; pp. 1591 - 1594
• Main Authors: Boot, J.D., Tarasevych, S., Sterk, P.J., Schoemaker, R.C., Wang, L., Amin, D., Cohen, A.F., Diamant, Z.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.12.2005; Elsevier; Elsevier Limited
• Subjects: Adult; Albuterol - therapeutic use; Allergen challenge; Allergens; Asthma; Asthma - drug therapy; Asthma - metabolism; Asthma - physiopathology; Biological and medical sciences; Breath Tests; Bronchial Provocation Tests; Bronchodilator Agents - therapeutic use; Chronic obstructive pulmonary disease, asthma; Exhaled nitric oxide; Female; Forced Expiratory Volume; Humans; Hypersensitivity, Delayed - drug therapy; Hypersensitivity, Delayed - metabolism; Hypersensitivity, Delayed - physiopathology; Male; Medical research; Medical sciences; Nitric Oxide - analysis; Pneumology; Time Factors; Allergen challenge; Exhaled nitric oxide; Asthma; Immunopathology; Lung disease; Allergy; Late; Respiratory disease; Increase; Nitric oxide; Bronchus disease; Obstructive pulmonary disease; Allergen
• ISSN: 0954-6111; 1532-3064
• DOI: 10.1016/j.rmed.2005.03.016

A clear-cut relationship of eNO and the airway calibre may have implications for the measurements.7-10 Late asthmatic airway response (LAR) to inhaled allergen, defined as a fall in forced expiratory volume in 1s (FEV1) of at least 15% from pre-allergen baseline,11 has been shown to be associated with airway inflammation, including increased levels of eNO.12 We hypothesized that eNO levels during LAR are related to the degree of airway narrowing. [...]we studied the effect of vigorous bronchodilation with inhaled salbutamol during LAR on eNO levels. Various studies in asthma showed decreases in eNO levels following bronchoconstrictor stimuli including methacholine, histamine, hypertonic saline, adenosine monophosphate (AMP) and exercise-induced bronchoconstriction.7,9,10 Alternatively, following inhalation of salbutamol, Silkoff and colleagues found increased levels of eNO corresponding with increases in FEV1 in asthmatic subjects in absence of allergen challenge.8 The present study combines all the above-mentioned observations: in agreement with Kharitonov's data,12 we found similar pre-bronchodilator eNO values during the LAR at 9h post-allergen.