Necrotizing periodontitis as a possible manifestation of common variable immunodeficiency

• Published in: International journal of oral and maxillofacial surgery Vol. 41; no. 12; pp. 1546 - 1549
• Main Authors: Dalla Torre, D, Burtscher, D, Jank, S, Kloss, F.R
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.12.2012; Elsevier
• Subjects: Adolescent; Biological and medical sciences; common variable immunodeficiency (CVID); Common Variable Immunodeficiency - complications; Dentistry; Facial bones, jaws, teeth, parodontium: diseases, semeiology; Female; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; immunodeficiency; immunoglobulin; Immunopathology; Medical sciences; necrotizing ulcerative periodontitis (NUP); Non tumoral diseases; Otorhinolaryngology. Stomatology; periodontitis; Periodontitis - complications; Periodontitis - diagnostic imaging; Radiography, Panoramic; Surgery; necrotizing ulcerative periodontitis (NUP); immunodeficiency; common variable immunodeficiency (CVID); immunoglobulin; periodontitis; Immunopathology; Immunoglobulins; Common variable immunodeficiency; Stomatology; Periodontal disease; Treatment; Immunoglobulinopathy; Periodontitis; Surgery; Ulceration
• ISSN: 0901-5027; 1399-0020
• DOI: 10.1016/j.ijom.2012.09.008

Abstract Common variable immunodeficiency (CVID) is an inherited disease characterized by hypogammaglobulinaemia and impaired humoural immunoresponse and is mainly associated with recurrent infections of the airway and the digestive tract. An 18-year old female with a diagnosis of CVID associated with a devastating necrotizing periodontitis, ultimately resulting in complete destruction of the periodontium and loss of all teeth, is reported. Clinical, biochemical, microbiological and radiographic examinations are presented. The report highlights the likely importance of immunoglobulin replacement and intensive dental hygiene in CVID patients, and the devastating effect of non-compliance in such patients.