Dialysis and renal transplantation in HIV-infected patients: a European survey

• Published in: Journal of acquired immune deficiency syndromes (1999) Vol. 55; no. 5; p. 582
• Main Authors: Trullas, Joan Carles, Mocroft, Amanda, Cofan, Federico, Tourret, Jérome, Moreno, Asunción, Bagnis, Corinne Isnard, Fux, Christoph Andreas, Katlama, Christine, Reiss, Peter, Lundgren, Jens, Gatell, Jose Maria, Kirk, Ole, Miró, Jose M
• Format: Journal Article
• Language: English
• Published: United States 15.12.2010
• Subjects: Adult; CD4 Lymphocyte Count; Cross-Sectional Studies; Europe; Female; Hepatitis Viruses; Hepatitis, Viral, Human - complications; Hepatitis, Viral, Human - epidemiology; HIV Infections - complications; HIV Infections - epidemiology; Humans; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - epidemiology; Kidney Transplantation; Male; Middle Aged; Renal Dialysis; Europe
• ISSN: 1944-7884
• DOI: 10.1097/qai.0b013e3181efbe59

To determine prevalence and characteristics of end-stage renal diseases (ESRD) [dialysis and renal transplantation (RT)] among European HIV-infected patients. Cross-sectional multicenter survey of EuroSIDA clinics during 2008. Prevalence of ESRD was 0.5%. Of 122 patients with ESRD 96 were on dialysis and 26 had received a RT. Median age was 47 years, 73% were males and 43% were black. Median duration of HIV infection was 11 years. Thirty-three percent had prior AIDS; 91% were receiving antiretrovirals; and 88% had undetectable viral load. Median CD4(+)T-cell count was 341 cells per cubic millimetre; 20.5% had hepatitis C coinfection. Most frequent causes of ESRD were HIV-associated nephropathy (46%) and other glomerulonephritis (28%). Hemodialysis (93%) was the most common dialysis modality; 34% of patients were on the RT waiting list. A poor HIV control was the reason for exclusion from RT waiting list in 22.4% of cases. All the RT recipients were all alive at the time of the survey. Acute rejection was reported in 8 patients (30%). Functioning graft was present in 21 (80%). This is the first multinational cross-sectional study of ESRD among European HIV population. Low prevalence of ESRD was found. Two-thirds of patients were excluded from RT for non-HIV/AIDS-related pathologies. Most patients had a functioning graft despite a high acute rejection rate.