Anterior Cingulate Cortex in Schema Assimilation and Expression

• Published in: Learning & memory (Cold Spring Harbor, N.Y.) Vol. 19; no. 8; pp. 315 - 318
• Main Authors: Wang, Szu-Han, Tse, Dorothy, Morris, Richard G. M
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.08.2012
• Subjects: 2-Amino-5-phosphonovalerate - pharmacology; 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology; Analysis of Variance; Animals; Association Learning - drug effects; Association Learning - physiology; Brain; Brief Communication; Cognitive Development; Cognitive Processes; Conditioning, Operant - drug effects; Conditioning, Operant - physiology; Cues; Early Growth Response Protein 1 - metabolism; Excitatory Amino Acid Antagonists - pharmacology; Gyrus Cinguli - drug effects; Gyrus Cinguli - physiology; Hippocampus - drug effects; Hippocampus - physiology; Human Body; Learning Processes; Male; Mental Recall - drug effects; Mental Recall - physiology; Neural Pathways - drug effects; Neural Pathways - physiology; Neurological Organization; Rats; Reaction Time - drug effects; Reward; Task Analysis; Time Factors
• ISSN: 1072-0502; 1549-5485; 1549-5485
• DOI: 10.1101/lm.026336.112

In humans and in animals, mental schemas can store information within an associative framework that enables rapid and efficient assimilation of new information. Using a hippocampal-dependent paired-associate task, we now report that the anterior cingulate cortex is part of a neocortical network of schema storage with NMDA receptor-mediated transmission critical for information updating, and AMPA receptor-mediated transmission required for the expression and updating of stored information.