A multinational, randomized, placebo-controlled trial to assess the immunogenicity, safety, and tolerability of live attenuated influenza vaccine coadministered with oral poliovirus vaccine in healthy young children

• Published in: Vaccine Vol. 27; no. 40; pp. 5472 - 5479
• Main Authors: Breiman, Robert F, Brooks, W. Abdullah, Goswami, Doli, Lagos, Rosanna, Borja-Tabora, Charissa, Lanata, Claudio F, Londoño, Jaime A. Cèspedes, Lum, Lucy Chai See, Rappaport, Ruth, Razmpour, Ahmad, Walker, Robert E, Gruber, William C, Forrest, Bruce D
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 04.09.2009; Elsevier; Elsevier Limited
• Subjects: Allergy and Immunology; Antibodies, Viral - blood; Applied microbiology; Biological and medical sciences; Child, Preschool; Children; Female; Fundamental and applied biological sciences. Psychology; Humans; Immunization; Immunization Schedule; Immunogenicity; Infant; Influenza; Influenza Vaccines - administration & dosage; Influenza Vaccines - adverse effects; Influenza Vaccines - immunology; Influenza, Human - prevention & control; Live attenuated influenza vaccine; Male; Microbiology; Miscellaneous; Oral poliovirus vaccine; Poliomyelitis; Poliomyelitis - prevention & control; Poliovirus Vaccine, Oral - administration & dosage; Poliovirus Vaccine, Oral - adverse effects; Poliovirus Vaccine, Oral - immunology; Public health; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Vaccines, Attenuated - administration & dosage; Vaccines, Attenuated - adverse effects; Vaccines, Attenuated - immunology; Virology; Asia; South America; Oral poliovirus vaccine; Live attenuated influenza vaccine; Children; Human; Picornaviridae; Enterovirus; Vaccine; Poliovirus; Infection; Virus; Immunogenicity; Viral disease; Influenza; Attenuated strain; Child
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2009.07.002

Abstract Live attenuated influenza vaccine (LAIV) provides a useful tool to rapidly immunize populations in the developing world to prevent influenza outbreaks. In this noninferiority trial conducted in Asia and South America, where oral poliovirus vaccine (OPV) is still used, 2503 children aged 6 to <36 months with three polio immunizations were randomized to receive LAIV + OPV, placebo + OPV, or LAIV only. Immune responses in children receiving concomitant LAIV + OPV were noninferior to those observed in recipients of either vaccine alone. Response rates for different poliovirus types were similar in recipients of LAIV + OPV and placebo + OPV. Response rates to all influenza strains were similar in LAIV + OPV and LAIV-only recipients. Concomitant OPV and LAIV were safely administered to young children.