Universal Marker and Detection Tool for Human Sarcoma Circulating Tumor Cells

• Published in: Cancer research (Chicago, Ill.) Vol. 74; no. 6; pp. 1645 - 1650
• Main Authors: Satelli, Arun, Mitra, Abhisek, Cutrera, Jeffry J., Devarie, Marcos, Xia, Xueqing, Ingram, Davis R., Dibra, Denada, Somaiah, Neeta, Torres, Keila E., Ravi, Vinod, Ludwig, Joseph A., Kleinerman, Eugenie S., Li, Shulin
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.03.2014
• Subjects: Antibodies, Monoclonal - chemistry; Antineoplastic agents; Base Sequence; Biological and medical sciences; Biomarkers, Tumor - metabolism; Cell Line, Tumor; DNA Mutational Analysis; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Gene Amplification; Human Umbilical Vein Endothelial Cells - metabolism; Humans; Medical sciences; Microscopy, Fluorescence; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Neoplastic Cells, Circulating - metabolism; Pharmacology. Drug treatments; Prognosis; Sarcoma - diagnosis; Sarcoma - metabolism; Sarcoma - pathology; Sensitivity and Specificity; Single-Cell Analysis; Tumor Suppressor Protein p53 - genetics; Tumors; Vimentin - immunology; Vimentin - metabolism; Human; Sarcoma; Biological marker; Malignant tumor; Diagnosis; Detection; Tumor cell; Cancer

To date, no specific marker exists for the detection of circulating tumor cells (CTC) from different types of sarcomas, though tools are available for detection of CTCs in peripheral blood of patients with cancer for epithelial cancers. Here, we report cell-surface vimentin (CSV) as an exclusive mar...