High incidence of chromosomal abnormalities in oocyte donors

Oocyte donors are chosen among phenotypically normal and fertile women who are not expected to carry any chromosomal abnormality. A high incidence of balanced structural chromosomal rearrangements has been found within oocyte donors. This result raises the question of a possible bias in their recrui...

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Bibliographic Details
Published inFertility and sterility Vol. 87; no. 2; pp. 439 - 441
Main Authors Ravel, Célia, M.D, Letur, Hélène, M.D, Lannou, Dominique Le, M.D., Ph.D, Barthélémy, Claire, M.D, Bresson, Jean Luc, M.D., Ph.D, Siffroi, Jean Pierre, M.D., Ph.D
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.02.2007
Elsevier Science
Subjects
Adult
Biological and medical sciences
Chromosome Aberrations - statistics & numerical data
Chromosome Disorders - epidemiology
Chromosome Disorders - genetics
Female
France - epidemiology
Gynecology. Andrology. Obstetrics
Humans
Incidence
Internal Medicine
Medical sciences
Obstetrics and Gynecology
Oocyte Donation - statistics & numerical data
Retrospective Studies
Tissue Donors - statistics & numerical data
France
Chromosomal aberration
Donor
Fertility
Germinal cell
Epidemiology
Oocyte
Incidence
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Summary:Oocyte donors are chosen among phenotypically normal and fertile women who are not expected to carry any chromosomal abnormality. A high incidence of balanced structural chromosomal rearrangements has been found within oocyte donors. This result raises the question of a possible bias in their recruitment with respect to their familial background and/or personal reproductive history.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0015-0282
1556-5653
DOI:10.1016/j.fertnstert.2006.06.053