Syntheses of Aminoalkylguanidine Derivatives

The hydrochlorides of N1-benzyl-2-methyl-1, 2-propanediamine (I) and 5-amino-1, 3-dibenzyl-5-methylhexahydropyrimidine (II) were debenzylated by the catalytic hydrogenation under pressure. 2-Methyl-1, 2-propanediamine (III) which obtained from I, was derived to monoguanidine compound. The structure...

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 15; no. 7; pp. 936 - 943
Main Authors Tsuji, Tadakazu, Momona, Hiroko, Ueda, Takeo
Format Journal Article
LanguageEnglish
Published Japan The Pharmaceutical Society of Japan 01.01.1967
Japan Science and Technology Agency
Subjects
Amines
Guanidines - chemical synthesis
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Summary:The hydrochlorides of N1-benzyl-2-methyl-1, 2-propanediamine (I) and 5-amino-1, 3-dibenzyl-5-methylhexahydropyrimidine (II) were debenzylated by the catalytic hydrogenation under pressure. 2-Methyl-1, 2-propanediamine (III) which obtained from I, was derived to monoguanidine compound. The structure of this compound was concluded to be (2-amino-2-methylpropyl) guanidine from the comparison of the infrared spectra of related compounds. 2-Methyl-1, 2, 3-propanetriamine obtained from II, its starting material II, and other ethylenediamine derivatives were also guanidilated by the action of S-methylisothiourea sulfate.
Bibliography:ObjectType-Article-1
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ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.15.936