Novel mechanism by which extracellular vesicles derived from Lactobacillus murinus alleviates deoxynivalenol-induced intestinal barrier disruption

• Published in: Environment international Vol. 185; p. 108525
• Main Authors: Fan, Jinping, Zhang, Yuhan, Zuo, Minyu, Ding, Shixuan, Li, Jingjing, Feng, Shengkai, Xiao, Yingping, Tao, Shiyu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.03.2024; Elsevier
• Subjects: Deoxynivalenol; environment; Extracellular vesicles; Gut barrier; interleukin-10; intestinal microorganisms; intestines; Lactobacillus murinus; Macrophage; macrophages; phenotype; pollutants; probiotics; protein synthesis; risk; tight junctions; toxicity; LmEVs; D-LA; Extracellular vesicles; TNF; iNOS; DON; ACE; CON; EVs; IL; Arg1; TBST; L. murinus; Deoxynivalenol; FMT; TGF; DAO; ZO-1; Gut barrier; CD206; NTA; Lactobacillus murinus; TEM; Macrophage; ELISA; TLR2

[Display omitted] •DON-induced gut toxicity is partly mediated by gut microbiota.•L. murinus is a potential probiotic against DON.•L. murinus and its EVs effectively alleviated DON-induced intestinal barrier disorder.•LmEVs upregulate TLR2 to promote M2 macrophage polarization to protect the gut bar...