Genetic analysis of mortality in murine angiostrongyliasis costaricensis using SMXA recombinant inbred mouse strains

• Published in: Parasitology international Vol. 49; no. 4; pp. 335 - 338
• Main Authors: Ishih, Akira, Ohno, Tamio, Nishimura, Masahiko, Terada, Mamoru
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ireland Ltd 01.12.2000
• Subjects: Angiostrongylus; Angiostrongylus costaricensis; Animals; chromosome 13; chromosome 17; chromosome 6; Genetic Linkage - genetics; Genetic Predisposition to Disease; Genetic susceptibility; Mice; Mice, Inbred Strains; Recombination, Genetic; SMXA RI mice; Strongylida Infections - genetics; Strongylida Infections - mortality; Genetic susceptibility; Angiostrongylus costaricensis; SMXA RI mice
• ISSN: 1383-5769; 1873-0329
• DOI: 10.1016/S1383-5769(00)00050-7

The SMXA recombinant inbred mouse strain set was produced by systematic inbreeding from the F2 generation of a cross between two progenitor inbred strains, A/J and SM/J, which differed markedly with respect to the patterns of infection with Angiostrongylus costaricensis. We have applied this set to genetic analysis of mouse susceptibility to this nematode infection. The mortality was variable among substrains of the SMXA RI strains, indicating the involvement of multiple genes. Linkage analysis showed several chromosomal regions closely linked to mortality; chromosome 6 ( D6Rik86, 87; P≦0.001), 10 ( D10Rik66– D10Mit12; P=0.0058), 13 ( D13Rik79, 80; P=0.0096) and 17 ( D17Mit28– D17Rik76; P=0.0088).