Clinical effect of MUC1 and its relevance to BRAF V600E mutation in papillary thyroid carcinoma: a case-control study
To investigate the clinical effects of on papillary thyroid cancer (PTC) and explore the relationship between expression and mutation. The data of 69 patients subjected to fine-needle aspiration biopsy in our hospital and 486 patient data downloaded from The Cancer Genome Atlas (TCGA) database were...
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Published in | Cancer management and research Vol. 10; pp. 1351 - 1358 |
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Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
New Zealand
Dove Medical Press Limited
01.01.2018
Taylor & Francis Ltd Dove Medical Press |
Subjects | |
Online Access | Get full text |
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Summary: | To investigate the clinical effects of
on papillary thyroid cancer (PTC) and explore the relationship between
expression and
mutation.
The data of 69 patients subjected to fine-needle aspiration biopsy in our hospital and 486 patient data downloaded from The Cancer Genome Atlas (TCGA) database were used. Univariate and multivariate analyses were performed.
The results on the 486 patients recorded in the TCGA indicated that high
expression was independently related to
mutation, lymph node metastasis (LNM), and unifocal type. In the 69 fine-needle aspiration biopsy patients with PTC, high
expression was significantly related to LNM and extrathyroid extension (ETE). The result of Pearson's correlation coefficient showed that
mutation and
expression were moderately correlated. Moreover, in the subgroup with low
expression, the patients with
mutation had higher ETE frequency and LNM than those without
mutation. In the subgroup with
mutation, patients with high
expression exhibited higher ETE frequency than those with low
expression, and high
expression occurred in older patients. In the subgroup with
wild-type mutation, patients with high
expression had a higher incidence of ETE and LNM than those with low expression.
We demonstrated that the
is an important oncogene in PTC and may have great significance on therapeutic cancer vaccine development. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work |
ISSN: | 1179-1322 1179-1322 |
DOI: | 10.2147/CMAR.S161501 |