An investigation of the parameters influencing the bioadhesive properties of Myverol 18–99/water gels

• Published in: Biomaterials Vol. 18; no. 1; pp. 63 - 67
• Main Authors: Geraghty, P.B., Attwood, D., Collett, J.H., Sharma, H., Dandiker, Y.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 1997; Elsevier Science
• Subjects: Adhesives; Animals; Bioadhesion; Biocompatible Materials - chemistry; Biocompatible Materials - metabolism; Biological and medical sciences; Female; Gels - chemistry; Gels - metabolism; GIT mucosa; Glycerides - chemistry; Glycerides - metabolism; Intestinal Mucosa - metabolism; Medical sciences; mono-olein; Rabbits; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Rats; Technology. Biomaterials. Equipments. Material. Instrumentation; Time Factors; Vagina - metabolism; vaginal mucosa; Water - chemistry; Water - metabolism; Bioadhesion; GIT mucosa; mono-olein; vaginal mucosa; Radionuclide study; Performance evaluation; Delivery system; Parameter estimation; Rabbit; Mucus; Scintigraphy; Lagomorpha; In vitro; Crystalline state; In vivo; Tissue; Vertebrata; Mammalia; Adhesive strength; Animal; Medical imagery; Properties of materials; Lyotropic state; Bioadhesive system; Medical application; Freeze
• ISSN: 0142-9612; 1878-5905
• DOI: 10.1016/S0142-9612(96)00087-7

An in vitro assessment was undertaken of the parameters influencing the bioadhesive strength of lyotropic liquid crystalline gels formed by the monoglyceride blend Myverol 18–99 and water. The gels were found to bind more strongly to a dry Perspex surface than to moist mucosal tissue and were shown to be weaker bioadhesives than Carbopol 934P and sodium alginate. The works of adhesion and forces of detachment were independent of contact time, were reduced by the presence of surface water and increased with an increase in the compression force, suggesting that interpenetration was not the mechanism of bioadhesion. The bioadhesion of Myverol 18–99/water gels appeared to be due to secondary chemical bonds, such as van der Waals forces, but was limited by their cohesive strength. An in vivo gel retention assessment by gamma scintigraphy showed that the gels were retained within the vaginal cavity for a period of at least 6 h.