Absence of association between a functional polymorphism of ALOX15 gene and infertility in endometriosis

• Published in: Fertility and sterility Vol. 91; no. 4; pp. 1414 - 1416
• Main Authors: Borghese, Bruno, M.D, Gayet, Vanessa, M.D, Chiche, Jean-Daniel, M.D, Vernerey, Déwi, M.Sc, de Ziegler, Dominique, M.D, Bonaiti-Pellié, Catherine, M.D, Chapron, Charles, M.D
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.04.2009; Elsevier
• Subjects: Arachidonate 15-Lipoxygenase - genetics; Biological and medical sciences; Birth control; Case-Control Studies; Endometriosis - genetics; Female; Female genital diseases; Gene Frequency - genetics; Genetic Predisposition to Disease - genetics; Gynecology. Andrology. Obstetrics; Humans; Infertility, Female - genetics; Internal Medicine; Medical sciences; Non tumoral diseases; Obstetrics and Gynecology; Polymorphism, Single Nucleotide - genetics; Risk Factors; Sterility. Assisted procreation; Gene; Gynecology; Uterine diseases; Endometriosis; Obstetrics; Sterility; Female genital diseases; Polymorphism
• ISSN: 0015-0282; 1556-5653
• DOI: 10.1016/j.fertnstert.2008.05.039

The aim of the present study, involving 463 women of reproductive age, was to evaluate for the first time the relationship between endometriosis, endometriosis-related infertility, and a recently described functional polymorphism in the ALOX15 gene, reported to be essential for implantation. In our study population, ALOX15 -292 C/T was not correlated either with the risk of developing an endometriosis or with the risk of infertility.