Increased formation of carcinogenic PAH metabolites in fish promoted by nitrite
Nitrite (NO 2 −), a highly reactive chemical species, accumulates in coastal waters as a result of pollution with nitrogenous waste and/or an imbalance in the bacterial processes of nitrification and denitrification. The present study probed the impact of nitrite (NO 2 −) on the metabolism of polycy...
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Published in | Environmental pollution (1987) Vol. 143; no. 1; pp. 174 - 177 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Elsevier Ltd
01.09.2006
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Nitrite (NO
2
−), a highly reactive chemical species, accumulates in coastal waters as a result of pollution with nitrogenous waste and/or an imbalance in the bacterial processes of nitrification and denitrification. The present study probed the impact of nitrite (NO
2
−) on the metabolism of polycyclic aromatic hydrocarbons (PAHs) in fish. In a laboratory experiment, exposure of euryhaline fish,
Oreochromis mossambicus to industrial effluents containing PAHs in the presence of NO
2
− enhanced the cytochrome P450-dependent biotransformation activity determined as 7-ethoxyresorufin-
O-deethylase (EROD), by nearly 36% compared to the value observed in the absence of NO
2
− (50.2
±
6.74
pmol resorufin min
−1
g
−1 liver). Fixed wavelength fluorescence measurements in bile revealed maximum enhancement to have occurred in the metabolites of benzo[
a]pyrene, a carcinogenic PAH. Lasting, sublethal physiological deterioration was apparent in fish exposed simultaneously to an oil refinery effluent and NO
2
−, from the unremittingly decreasing liver somatic index, even after the withdrawal of the contaminants.
Nitrite increased formation of carcinogenic PAH metabolites in fish. |
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Bibliography: | http://dx.doi.org/10.1016/j.envpol.2005.10.043 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
ISSN: | 0269-7491 1873-6424 |
DOI: | 10.1016/j.envpol.2005.10.043 |