Identification of an early subset of cerebellar nuclei neurons in mice

Cerebellar nuclei (CN) neurons serve as the primary output of the cerebellum and originate from the cerebellar primordium at early stages of cerebellar development. These neurons are diverse, integrating information from the cerebellar cortex and relaying it to various brain regions. Employing vario...

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Published ineLife Vol. 13
Main Authors Rahimi-Balaei, Maryam, Amiri, Shayan, Lamonerie, Thomas, Wu, Sih-Rong, Zoghbi, Huda Y, Consalez, G Giacomo, Goldowitz, Daniel, Marzban, Hassan
Format Journal Article
LanguageEnglish
Published England eLife Science Publications, Ltd 16.12.2024
eLife Sciences Publications, Ltd
eLife Sciences Publications Ltd
Subjects
Analysis
Animals
Atoh1
Basic Helix-Loop-Helix Transcription Factors - genetics
Basic Helix-Loop-Helix Transcription Factors - metabolism
cerebellar nuclei
Cerebellar Nuclei - cytology
Cerebellar Nuclei - embryology
Flow Cytometry
Immunohistochemistry
MEIS2
Mice
Mice, Knockout
Neurons
Neurons - cytology
Neurons - physiology
Neuroscience
Otx Transcription Factors - genetics
Otx Transcription Factors - metabolism
OTX2
SNCA
Zoghbi, Huda
United States
Ontario
mouse
cerebellar nuclei
neuroscience
OTX2
MEIS2
Atoh1
SNCA
Online AccessGet full text
ISSN2050-084X
2050-084X
DOI10.7554/eLife.93778

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Abstract Cerebellar nuclei (CN) neurons serve as the primary output of the cerebellum and originate from the cerebellar primordium at early stages of cerebellar development. These neurons are diverse, integrating information from the cerebellar cortex and relaying it to various brain regions. Employing various methodologies, we have characterized a specific subset of CN neurons that do not originate from the rhombic lip or ventricular zone of the cerebellar primordium. Embryos were collected at early stages of development and processed for immunohistochemistry (IHC), western blotting, in situ hybridization (ISH), embryonic culture, DiI labeling, and flow cytometry analysis (FCM). Our findings indicate that a subset of CN neurons expressing α-synuclein (SNCA), OTX2, MEIS2, and p75NTR (NGFR) are located in the rostroventral region of the NTZ. While CN neurons derived from the rhombic lip are positioned in the caudodorsal area of the NTZ in the cerebellar primordium. Utilizing Otx2-GFP and Atoh1 -/- mice, we have determined that these cells do not originate from the germinal zone of the cerebellar primordium. These results suggest the existence of a novel extrinsic germinal zone for the cerebellar primordium, possibly the mesencephalon, from which early CN neurons originate.
AbstractList Cerebellar nuclei (CN) neurons serve as the primary output of the cerebellum and originate from the cerebellar primordium at early stages of cerebellar development. These neurons are diverse, integrating information from the cerebellar cortex and relaying it to various brain regions. Employing various methodologies, we have characterized a specific subset of CN neurons that do not originate from the rhombic lip or ventricular zone of the cerebellar primordium. Embryos were collected at early stages of development and processed for immunohistochemistry (IHC), western blotting, in situ hybridization (ISH), embryonic culture, DiI labeling, and flow cytometry analysis (FCM). Our findings indicate that a subset of CN neurons expressing α-synuclein (SNCA), OTX2, MEIS2, and p75NTR (NGFR) are located in the rostroventral region of the NTZ. While CN neurons derived from the rhombic lip are positioned in the caudodorsal area of the NTZ in the cerebellar primordium. Utilizing Otx2-GFP and Atoh1 -/- mice, we have determined that these cells do not originate from the germinal zone of the cerebellar primordium. These results suggest the existence of a novel extrinsic germinal zone for the cerebellar primordium, possibly the mesencephalon, from which early CN neurons originate.
Cerebellar nuclei (CN) neurons serve as the primary output of the cerebellum and originate from the cerebellar primordium at early stages of cerebellar development. These neurons are diverse, integrating information from the cerebellar cortex and relaying it to various brain regions. Employing various methodologies, we have characterized a specific subset of CN neurons that do not originate from the rhombic lip or ventricular zone of the cerebellar primordium. Embryos were collected at early stages of development and processed for immunohistochemistry (IHC), western blotting, in situ hybridization (ISH), embryonic culture, DiI labeling, and flow cytometry analysis (FCM). Our findings indicate that a subset of CN neurons expressing [alpha]-synuclein (SNCA), OTX2, MEIS2, and p75NTR (NGFR) are located in the rostroventral region of the NTZ. While CN neurons derived from the rhombic lip are positioned in the caudodorsal area of the NTZ in the cerebellar primordium. Utilizing Otx2-GFP and Atoh1.sup.-/- mice, we have determined that these cells do not originate from the germinal zone of the cerebellar primordium. These results suggest the existence of a novel extrinsic germinal zone for the cerebellar primordium, possibly the mesencephalon, from which early CN neurons originate.
Cerebellar nuclei (CN) neurons serve as the primary output of the cerebellum and originate from the cerebellar primordium at early stages of cerebellar development. These neurons are diverse, integrating information from the cerebellar cortex and relaying it to various brain regions. Employing various methodologies, we have characterized a specific subset of CN neurons that do not originate from the rhombic lip or ventricular zone of the cerebellar primordium. Embryos were collected at early stages of development and processed for immunohistochemistry (IHC), western blotting, in situ hybridization (ISH), embryonic culture, DiI labeling, and flow cytometry analysis (FCM). Our findings indicate that a subset of CN neurons expressing α-synuclein (SNCA), OTX2, MEIS2, and p75NTR (NGFR) are located in the rostroventral region of the NTZ. While CN neurons derived from the rhombic lip are positioned in the caudodorsal area of the NTZ in the cerebellar primordium. Utilizing Otx2-GFP and mice, we have determined that these cells do not originate from the germinal zone of the cerebellar primordium. These results suggest the existence of a novel extrinsic germinal zone for the cerebellar primordium, possibly the mesencephalon, from which early CN neurons originate.
Cerebellar nuclei (CN) neurons serve as the primary output of the cerebellum and originate from the cerebellar primordium at early stages of cerebellar development. These neurons are diverse, integrating information from the cerebellar cortex and relaying it to various brain regions. Employing various methodologies, we have characterized a specific subset of CN neurons that do not originate from the rhombic lip or ventricular zone of the cerebellar primordium. Embryos were collected at early stages of development and processed for immunohistochemistry (IHC), western blotting, in situ hybridization (ISH), embryonic culture, DiI labeling, and flow cytometry analysis (FCM). Our findings indicate that a subset of CN neurons expressing α-synuclein (SNCA), OTX2, MEIS2, and p75NTR (NGFR) are located in the rostroventral region of the NTZ. While CN neurons derived from the rhombic lip are positioned in the caudodorsal area of the NTZ in the cerebellar primordium. Utilizing Otx2-GFP and Atoh1-/- mice, we have determined that these cells do not originate from the germinal zone of the cerebellar primordium. These results suggest the existence of a novel extrinsic germinal zone for the cerebellar primordium, possibly the mesencephalon, from which early CN neurons originate.Cerebellar nuclei (CN) neurons serve as the primary output of the cerebellum and originate from the cerebellar primordium at early stages of cerebellar development. These neurons are diverse, integrating information from the cerebellar cortex and relaying it to various brain regions. Employing various methodologies, we have characterized a specific subset of CN neurons that do not originate from the rhombic lip or ventricular zone of the cerebellar primordium. Embryos were collected at early stages of development and processed for immunohistochemistry (IHC), western blotting, in situ hybridization (ISH), embryonic culture, DiI labeling, and flow cytometry analysis (FCM). Our findings indicate that a subset of CN neurons expressing α-synuclein (SNCA), OTX2, MEIS2, and p75NTR (NGFR) are located in the rostroventral region of the NTZ. While CN neurons derived from the rhombic lip are positioned in the caudodorsal area of the NTZ in the cerebellar primordium. Utilizing Otx2-GFP and Atoh1-/- mice, we have determined that these cells do not originate from the germinal zone of the cerebellar primordium. These results suggest the existence of a novel extrinsic germinal zone for the cerebellar primordium, possibly the mesencephalon, from which early CN neurons originate.
Cerebellar nuclei (CN) neurons serve as the primary output of the cerebellum and originate from the cerebellar primordium at early stages of cerebellar development. These neurons are diverse, integrating information from the cerebellar cortex and relaying it to various brain regions. Employing various methodologies, we have characterized a specific subset of CN neurons that do not originate from the rhombic lip or ventricular zone of the cerebellar primordium. Embryos were collected at early stages of development and processed for immunohistochemistry (IHC), western blotting, in situ hybridization (ISH), embryonic culture, DiI labeling, and flow cytometry analysis (FCM). Our findings indicate that a subset of CN neurons expressing α-synuclein (SNCA), OTX2, MEIS2, and p75NTR (NGFR) are located in the rostroventral region of the NTZ. While CN neurons derived from the rhombic lip are positioned in the caudodorsal area of the NTZ in the cerebellar primordium. Utilizing Otx2-GFP and Atoh1-/- mice, we have determined that these cells do not originate from the germinal zone of the cerebellar primordium. These results suggest the existence of a novel extrinsic germinal zone for the cerebellar primordium, possibly the mesencephalon, from which early CN neurons originate.
Audience Academic
Author Amiri, Shayan
Zoghbi, Huda Y
Rahimi-Balaei, Maryam
Wu, Sih-Rong
Goldowitz, Daniel
Consalez, G Giacomo
Marzban, Hassan
Lamonerie, Thomas
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Cites_doi 10.1038/43664
10.1016/j.pneurobio.2004.03.004
10.1242/dev.128.24.4979
10.1242/dev.01220
10.1007/978-94-007-1333-8
10.1371/journal.pone.0222234
10.1002/dvdy.21571
10.3791/60168
10.1016/j.neuron.2008.08.024
10.1007/s12311-013-0502-y
10.1016/S0021-9258(18)70015-X
10.1038/35053516
10.1016/j.neuron.2005.08.024
10.1016/j.stemcr.2015.07.002
10.7554/eLife.50617
10.1016/j.neuron.2005.08.028
10.1007/s12311-022-01506-0
10.1016/j.brainres.2007.01.031
10.7554/eLife.58613
10.1111/j.1460-9568.1989.tb00362.x
10.1523/JNEUROSCI.3493-06.2006
10.1073/pnas.0910786107
10.1016/0006-8993(75)90124-9
10.1016/j.brainresrev.2005.03.001
10.1242/dev.121.12.3935
10.1242/dev.075861
10.1016/s0955-0674(00)00161-7
10.1126/science.7624797
10.1002/dvdy.20611
10.1523/JNEUROSCI.13-01-00285.1993
10.1242/dev.202502
10.1038/358687a0
10.1016/s0166-2236(98)01313-7
10.3389/fnmol.2022.921901
10.1242/dev.037770
10.1016/0014-4886(61)90055-3
10.1007/s12311-013-0511-x
10.1007/s00429-019-01916-7
10.7554/eLife.42388
10.1523/JNEUROSCI.5203-05.2006
10.3390/ijms17010115
10.1002/cne.10719
10.1007/s00335-006-0033-7
10.1016/j.neuroscience.2008.02.036
10.1016/j.neulet.2009.06.003
10.1038/36579
10.1073/pnas.87.3.923
10.1016/S1364-6613(98)01210-8
10.1002/(SICI)1097-0177(199710)210:2<184::AID-AJA10>3.0.CO;2-E
10.1186/1471-213X-7-122
10.1371/journal.pone.0094327
10.1126/science.1672471
10.1038/nn1102-1131
10.1007/s10571-009-9473-4
10.1186/s12861-015-0093-6
10.1038/35081558
10.3389/fnana.2013.00018
10.1186/1471-2202-11-136
10.3389/fncel.2018.00484
10.1089/scd.2008.0362
10.1186/1749-8104-9-1
10.3389/fncel.2014.00450
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Keywords mouse
cerebellar nuclei
neuroscience
OTX2
MEIS2
Atoh1
SNCA
Language English
License 2024, Rahimi-Balaei et al.
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References Djelloul (bib12) 2015; 5
Marzban (bib36) 2007; 1141
Marzban (bib35) 2003; 462
Miale (bib40) 1961; 4
Zordan (bib61) 2008; 237
Dechant (bib11) 2002; 5
Wizeman (bib57) 2019; 8
Ben-Arie (bib5) 1997; 390
Rahimi-Balaei (bib48) 2019; 14
Alvarado-Mallart (bib2) 2005; 49
Willett (bib56) 2019; 8
Bobak (bib7) 2009; 461
Agoston (bib1) 2009; 136
Martinez (bib34) 2013; 7
Bailey (bib4) 2014; 9
Kurokawa (bib28) 2004; 131
Easter (bib13) 1993; 13
Martinez (bib33) 1989; 1
Voogd (bib53) 1998; 2
Hanks (bib20) 1995; 269
Fujita (bib17) 2020; 9
Rahimi-Balaei (bib47) 2018; 12
Rahimi Balaei (bib46) 2016; 17
Cecconi (bib8) 1997; 210
Morales (bib43) 2006; 26
Stainier (bib52) 1990; 87
Millet (bib42) 1999; 401
Machold (bib30) 2005; 48
Wang (bib54) 2001; 2
Krishnamurthy (bib27) 2024; 151
Jiang (bib22) 2009; 18
Millen (bib41) 1995; 121
Zylka (bib62) 2008; 60
Simeone (bib50) 1992; 358
Chizhikov (bib9) 2006; 17
Li (bib29) 2001; 128
Machon (bib31) 2015; 15
Chizhikov (bib10) 2010; 107
Koziol (bib26) 2014; 13
Fossat (bib16) 2007; 7
Pierce (bib45) 1975; 95
Wang (bib55) 2005; 48
Manto (bib32) 2012
Goldowitz (bib18) 1998; 21
Green (bib19) 2014; 9
Hokin (bib21) 1959; 234
Bernabeu (bib6) 2010; 11
Florio (bib15) 2012; 139
Kebschull (bib25) 2024; 23
Zhong (bib60) 2010; 30
Shabanipour (bib49) 2019; 01
Fink (bib14) 2006; 26
Joyner (bib24) 2000; 12
Nichols (bib44) 2006; 235
Joyner (bib23) 1991; 251
Bailey (bib3) 2013; 12
Wurst (bib59) 2001; 2
Marzban (bib37) 2008; 153
Marzban (bib38) 2014; 8
Marzban (bib39) 2019; 224
Wu (bib58) 2022; 15
Sotelo (bib51) 2004; 72
References_xml – volume: 401
  start-page: 161
  year: 1999
  ident: bib42
  article-title: A role for Gbx2 in repression of Otx2 and positioning the mid/hindbrain organizer
  publication-title: Nature
  doi: 10.1038/43664
– volume: 72
  start-page: 295
  year: 2004
  ident: bib51
  article-title: Cellular and genetic regulation of the development of the cerebellar system
  publication-title: Progress in Neurobiology
  doi: 10.1016/j.pneurobio.2004.03.004
– volume: 128
  start-page: 4979
  year: 2001
  ident: bib29
  article-title: Otx2 and Gbx2 are required for refinement and not induction of mid-hindbrain gene expression
  publication-title: Development
  doi: 10.1242/dev.128.24.4979
– volume: 131
  start-page: 3319
  year: 2004
  ident: bib28
  article-title: Regulation of Otx2 expression and its functions in mouse forebrain and midbrain
  publication-title: Development
  doi: 10.1242/dev.01220
– volume-title: Handbook of the Cerebellum and Cerebellar Disorders
  year: 2012
  ident: bib32
  doi: 10.1007/978-94-007-1333-8
– volume: 14
  year: 2019
  ident: bib48
  article-title: Loss of prostatic acid phosphatase and α-synuclein cause motor circuit degeneration without altering cerebellar patterning
  publication-title: PLOS ONE
  doi: 10.1371/journal.pone.0222234
– volume: 237
  start-page: 1726
  year: 2008
  ident: bib61
  article-title: Comparative analysis of proneural gene expression in the embryonic cerebellum
  publication-title: Developmental Dynamics
  doi: 10.1002/dvdy.21571
– volume: 01
  year: 2019
  ident: bib49
  article-title: Primary culture of neurons isolated from embryonic mouse cerebellum
  publication-title: Journal of Visualized Experiments
  doi: 10.3791/60168
– volume: 60
  start-page: 111
  year: 2008
  ident: bib62
  article-title: Prostatic acid phosphatase is an ectonucleotidase and suppresses pain by generating adenosine
  publication-title: Neuron
  doi: 10.1016/j.neuron.2008.08.024
– volume: 12
  start-page: 870
  year: 2013
  ident: bib3
  article-title: Spatial and temporal expression of lysosomal acid phosphatase 2 (ACP2) reveals dynamic patterning of the mouse cerebellar cortex
  publication-title: Cerebellum
  doi: 10.1007/s12311-013-0502-y
– volume: 234
  start-page: 1381
  year: 1959
  ident: bib21
  article-title: The synthesis of phosphatidic acid from diglyceride and adenosine triphosphate in extracts of brain microsomes
  publication-title: The Journal of Biological Chemistry
  doi: 10.1016/S0021-9258(18)70015-X
– volume: 2
  start-page: 99
  year: 2001
  ident: bib59
  article-title: Neural plate patterning: upstream and downstream of the isthmic organizer
  publication-title: Nature Reviews. Neuroscience
  doi: 10.1038/35053516
– volume: 48
  start-page: 31
  year: 2005
  ident: bib55
  article-title: Math1 expression redefines the rhombic lip derivatives and reveals novel lineages within the brainstem and cerebellum
  publication-title: Neuron
  doi: 10.1016/j.neuron.2005.08.024
– volume: 5
  start-page: 174
  year: 2015
  ident: bib12
  article-title: Alpha-synuclein expression in the oligodendrocyte lineage: an in vitro and in vivo study using rodent and human models
  publication-title: Stem Cell Reports
  doi: 10.1016/j.stemcr.2015.07.002
– volume: 8
  year: 2019
  ident: bib56
  article-title: Cerebellar nuclei excitatory neurons regulate developmental scaling of presynaptic Purkinje cell number and organ growth
  publication-title: eLife
  doi: 10.7554/eLife.50617
– volume: 48
  start-page: 17
  year: 2005
  ident: bib30
  article-title: Math1 is expressed in temporally discrete pools of cerebellar rhombic-lip neural progenitors
  publication-title: Neuron
  doi: 10.1016/j.neuron.2005.08.028
– volume: 23
  start-page: 620
  year: 2024
  ident: bib25
  article-title: Cerebellum lecture: the cerebellar nuclei-core of the cerebellum
  publication-title: Cerebellum
  doi: 10.1007/s12311-022-01506-0
– volume: 1141
  start-page: 25
  year: 2007
  ident: bib36
  article-title: Fibroblast growth factor promotes the development of deep cerebellar nuclear neurons in dissociated mouse cerebellar cultures
  publication-title: Brain Research
  doi: 10.1016/j.brainres.2007.01.031
– volume: 9
  year: 2020
  ident: bib17
  article-title: Modular output circuits of the fastigial nucleus for diverse motor and nonmotor functions of the cerebellar vermis
  publication-title: eLife
  doi: 10.7554/eLife.58613
– volume: 1
  start-page: 549
  year: 1989
  ident: bib33
  article-title: Rostral cerebellum originates from the caudal portion of the so-called “Mesencephalic” vesicle: a study using chick/quail chimeras
  publication-title: The European Journal of Neuroscience
  doi: 10.1111/j.1460-9568.1989.tb00362.x
– volume: 26
  start-page: 12226
  year: 2006
  ident: bib43
  article-title: Molecular markers of neuronal progenitors in the embryonic cerebellar anlage
  publication-title: The Journal of Neuroscience
  doi: 10.1523/JNEUROSCI.3493-06.2006
– volume: 107
  start-page: 10725
  year: 2010
  ident: bib10
  article-title: Lmx1a regulates fates and location of cells originating from the cerebellar rhombic lip and telencephalic cortical hem
  publication-title: PNAS
  doi: 10.1073/pnas.0910786107
– volume: 95
  start-page: 503
  year: 1975
  ident: bib45
  article-title: Histogenesis of the deep cerebellar nuclei in the mouse: an autoradiographic study
  publication-title: Brain Research
  doi: 10.1016/0006-8993(75)90124-9
– volume: 49
  start-page: 109
  year: 2005
  ident: bib2
  article-title: The chick/quail transplantation model: discovery of the isthmic organizer center
  publication-title: Brain Research. Brain Research Reviews
  doi: 10.1016/j.brainresrev.2005.03.001
– volume: 121
  start-page: 3935
  year: 1995
  ident: bib41
  article-title: A role for En-2 and other murine homologues of Drosophila segment polarity genes in regulating positional information in the developing cerebellum
  publication-title: Development
  doi: 10.1242/dev.121.12.3935
– volume: 139
  start-page: 2308
  year: 2012
  ident: bib15
  article-title: Neurogenin 2 regulates progenitor cell-cycle progression and Purkinje cell dendritogenesis in cerebellar development
  publication-title: Development
  doi: 10.1242/dev.075861
– volume: 12
  start-page: 736
  year: 2000
  ident: bib24
  article-title: Otx2, Gbx2 and Fgf8 interact to position and maintain a mid-hindbrain organizer
  publication-title: Current Opinion in Cell Biology
  doi: 10.1016/s0955-0674(00)00161-7
– volume: 269
  start-page: 679
  year: 1995
  ident: bib20
  article-title: Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2
  publication-title: Science
  doi: 10.1126/science.7624797
– volume: 235
  start-page: 285
  year: 2006
  ident: bib44
  article-title: Migratory routes and fates of cells transcribing the Wnt-1 gene in the murine hindbrain
  publication-title: Developmental Dynamics
  doi: 10.1002/dvdy.20611
– volume: 13
  start-page: 285
  year: 1993
  ident: bib13
  article-title: Initial tract formation in the mouse brain
  publication-title: The Journal of Neuroscience
  doi: 10.1523/JNEUROSCI.13-01-00285.1993
– volume: 151
  year: 2024
  ident: bib27
  article-title: Engrailed transcription factors direct excitatory cerebellar neuron diversity and survival
  publication-title: Development
  doi: 10.1242/dev.202502
– volume: 358
  start-page: 687
  year: 1992
  ident: bib50
  article-title: Nested expression domains of four homeobox genes in developing rostral brain
  publication-title: Nature
  doi: 10.1038/358687a0
– volume: 21
  start-page: 375
  year: 1998
  ident: bib18
  article-title: The cells and molecules that make a cerebellum
  publication-title: Trends in Neurosciences
  doi: 10.1016/s0166-2236(98)01313-7
– volume: 15
  year: 2022
  ident: bib58
  article-title: The transcription factor Pou3f1 sheds light on the development and molecular diversity of glutamatergic cerebellar nuclear neurons in the mouse
  publication-title: Frontiers in Molecular Neuroscience
  doi: 10.3389/fnmol.2022.921901
– volume: 136
  start-page: 3311
  year: 2009
  ident: bib1
  article-title: Meis2 competes with the Groucho co-repressor Tle4 for binding to Otx2 and specifies tectal fate without induction of a secondary midbrain-hindbrain boundary organizer
  publication-title: Development
  doi: 10.1242/dev.037770
– volume: 4
  start-page: 277
  year: 1961
  ident: bib40
  article-title: An autoradiographic analysis of histogenesis in the mouse cerebellum
  publication-title: Experimental Neurology
  doi: 10.1016/0014-4886(61)90055-3
– volume: 13
  start-page: 151
  year: 2014
  ident: bib26
  article-title: Consensus paper: the cerebellum’s role in movement and cognition
  publication-title: Cerebellum
  doi: 10.1007/s12311-013-0511-x
– volume: 224
  start-page: 2421
  year: 2019
  ident: bib39
  article-title: Early trigeminal ganglion afferents enter the cerebellum before the Purkinje cells are born and target the nuclear transitory zone
  publication-title: Brain Structure and Function
  doi: 10.1007/s00429-019-01916-7
– volume: 8
  year: 2019
  ident: bib57
  article-title: Specification of diverse cell types during early neurogenesis of the mouse cerebellum
  publication-title: eLife
  doi: 10.7554/eLife.42388
– volume: 26
  start-page: 3066
  year: 2006
  ident: bib14
  article-title: Development of the deep cerebellar nuclei: transcription factors and cell migration from the rhombic lip
  publication-title: The Journal of Neuroscience
  doi: 10.1523/JNEUROSCI.5203-05.2006
– volume: 17
  year: 2016
  ident: bib46
  article-title: Cerebellar expression of the neurotrophin receptor p75 in naked-ataxia mutant mouse
  publication-title: International Journal of Molecular Sciences
  doi: 10.3390/ijms17010115
– volume: 462
  start-page: 286
  year: 2003
  ident: bib35
  article-title: Expression of the immunoglobulin superfamily neuroplastin adhesion molecules in adult and developing mouse cerebellum and their localisation to parasagittal stripes
  publication-title: The Journal of Comparative Neurology
  doi: 10.1002/cne.10719
– volume: 17
  start-page: 1025
  year: 2006
  ident: bib9
  article-title: Molecular definition of an allelic series of mutations disrupting the mouse Lmx1a (dreher) gene
  publication-title: Mammalian Genome
  doi: 10.1007/s00335-006-0033-7
– volume: 153
  start-page: 1190
  year: 2008
  ident: bib37
  article-title: A novel transverse expression domain in the mouse cerebellum revealed by A neurofilament-associated antigen
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2008.02.036
– volume: 461
  start-page: 223
  year: 2009
  ident: bib7
  article-title: Evidence against involvement of Bmp receptor 1b signaling in fate specification of the chick mesencephalic alar plate at HH16
  publication-title: Neuroscience Letters
  doi: 10.1016/j.neulet.2009.06.003
– volume: 390
  start-page: 169
  year: 1997
  ident: bib5
  article-title: Math1 is essential for genesis of cerebellar granule neurons
  publication-title: Nature
  doi: 10.1038/36579
– volume: 87
  start-page: 923
  year: 1990
  ident: bib52
  article-title: Pioneer neurons in the mouse trigeminal sensory system
  publication-title: PNAS
  doi: 10.1073/pnas.87.3.923
– volume: 2
  start-page: 307
  year: 1998
  ident: bib53
  article-title: The anatomy of the cerebellum
  publication-title: Trends in Cognitive Sciences
  doi: 10.1016/S1364-6613(98)01210-8
– volume: 210
  start-page: 184
  year: 1997
  ident: bib8
  article-title: Expression ofMeis2, aKnotted-related murine homeobox gene, indicates a role in the differentiation of the forebrain and the somitic mesoderm
  publication-title: Developmental Dynamics
  doi: 10.1002/(SICI)1097-0177(199710)210:2<184::AID-AJA10>3.0.CO;2-E
– volume: 7
  year: 2007
  ident: bib16
  article-title: A new GFP-tagged line reveals unexpected Otx2 protein localization in retinal photoreceptors
  publication-title: BMC Developmental Biology
  doi: 10.1186/1471-213X-7-122
– volume: 9
  year: 2014
  ident: bib4
  article-title: Purkinje cell compartmentation in the cerebellum of the lysosomal Acid phosphatase 2 mutant mouse (nax - naked-ataxia mutant mouse)
  publication-title: PLOS ONE
  doi: 10.1371/journal.pone.0094327
– volume: 251
  start-page: 1239
  year: 1991
  ident: bib23
  article-title: Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox
  publication-title: Science
  doi: 10.1126/science.1672471
– volume: 5
  start-page: 1131
  year: 2002
  ident: bib11
  article-title: The neurotrophin receptor p75(NTR): novel functions and implications for diseases of the nervous system
  publication-title: Nature Neuroscience
  doi: 10.1038/nn1102-1131
– volume: 30
  start-page: 469
  year: 2010
  ident: bib60
  article-title: Expression and subcellular location of alpha-synuclein during mouse-embryonic development
  publication-title: Cellular and Molecular Neurobiology
  doi: 10.1007/s10571-009-9473-4
– volume: 15
  year: 2015
  ident: bib31
  article-title: Meis2 is essential for cranial and cardiac neural crest development
  publication-title: BMC Developmental Biology
  doi: 10.1186/s12861-015-0093-6
– volume: 2
  start-page: 484
  year: 2001
  ident: bib54
  article-title: Genetic regulation of cerebellar development
  publication-title: Nature Reviews Neuroscience
  doi: 10.1038/35081558
– volume: 7
  year: 2013
  ident: bib34
  article-title: Cellular and molecular basis of cerebellar development
  publication-title: Frontiers in Neuroanatomy
  doi: 10.3389/fnana.2013.00018
– volume: 11
  year: 2010
  ident: bib6
  article-title: The p75 neurotrophin receptor is expressed by adult mouse dentate progenitor cells and regulates neuronal and non-neuronal cell genesis
  publication-title: BMC Neuroscience
  doi: 10.1186/1471-2202-11-136
– volume: 12
  year: 2018
  ident: bib47
  article-title: Neuronal migration du migration during development of the cerebring development of the cerebellum
  publication-title: Frontiers in Cellular Neuroscience
  doi: 10.3389/fncel.2018.00484
– volume: 18
  start-page: 1059
  year: 2009
  ident: bib22
  article-title: Isolation and characterization of neural crest stem cells derived from in vitro-differentiated human embryonic stem cells
  publication-title: Stem Cells and Development
  doi: 10.1089/scd.2008.0362
– volume: 9
  year: 2014
  ident: bib19
  article-title: Developmental origins of diversity in cerebellar output nuclei
  publication-title: Neural Development
  doi: 10.1186/1749-8104-9-1
– volume: 8
  year: 2014
  ident: bib38
  article-title: Cellular commitment in the developing cerebellum
  publication-title: Frontiers in Cellular Neuroscience
  doi: 10.3389/fncel.2014.00450
RelatedPersons Zoghbi, Huda
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SubjectTerms Analysis
Animals
Atoh1
Basic Helix-Loop-Helix Transcription Factors - genetics
Basic Helix-Loop-Helix Transcription Factors - metabolism
cerebellar nuclei
Cerebellar Nuclei - cytology
Cerebellar Nuclei - embryology
Flow Cytometry
Immunohistochemistry
MEIS2
Mice
Mice, Knockout
Neurons
Neurons - cytology
Neurons - physiology
Neuroscience
Otx Transcription Factors - genetics
Otx Transcription Factors - metabolism
OTX2
SNCA
Zoghbi, Huda
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Title Identification of an early subset of cerebellar nuclei neurons in mice
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