Classification of reactions to nonsteroidal antiinflammatory drugs

Hypersensitivity reactions to NSAIDs may occur in susceptible individuals and vary in symptom (skin, respiratory tract, and solid organs), severity (from mild skin or respiratory reactions to severe generalized) and timing (from acute to delayed). The current classification of NSAID-induced reaction...

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Bibliographic Details
Published inImmunology and allergy clinics of North America Vol. 33; no. 2; p. 135
Main Authors Kowalski, Marek L, Stevenson, Donald D
Format Journal Article
LanguageEnglish
Published United States 01.05.2013
Subjects
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Anti-Inflammatory Agents, Non-Steroidal - history
Aspirin - adverse effects
Drug Hypersensitivity - diagnosis
Drug Hypersensitivity - immunology
History, 20th Century
Humans
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Summary:Hypersensitivity reactions to NSAIDs may occur in susceptible individuals and vary in symptom (skin, respiratory tract, and solid organs), severity (from mild skin or respiratory reactions to severe generalized) and timing (from acute to delayed). The current classification of NSAID-induced reactions emerged with the understanding of the pathologic mechanism of reactions to NSAIDs which may be either non-allergic (related to cyclooxygenase inhibition) or immunologically mediated. In this chapter we discuss the implications of accurate NSAIDs hypersensitivity classification for proper diagnosis and patient management.
ISSN:1557-8607
DOI:10.1016/j.iac.2012.10.008