APOBEC3H polymorphisms and susceptibility to HIV-1 infection in an Indian population

• Published in: Journal of human genetics Vol. 61; no. 3; pp. 263 - 265
• Main Authors: Naruse, Taeko K, Sakurai, Daisuke, Ohtani, Hitoshi, Sharma, Gaurav, Sharma, Surendra K, Vajpayee, Madhu, Mehra, Narinder K, Kaur, Gurvinder, Kimura, Akinori
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.03.2016
• Subjects: APOBEC Deaminases - genetics; Case-Control Studies; Genetic Predisposition to Disease; HIV Infections - genetics; HIV-1; Human immunodeficiency virus; Human immunodeficiency virus 1; Humans; India
• ISSN: 1434-5161; 1435-232X
• DOI: 10.1038/jhg.2015.136

Human APOBEC3H (A3H) is a member of APOBEC cytidine deaminase family intensively constraining the HIV-1 replication. A3H is known to be polymorphic with different protein stability and anti-HIV-1 activity in vitro. We recently reported that A3H haplotypes composed of two functional polymorphisms, rs139292 (N15del) and rs139297 (G105R), were associated with the susceptibility to HIV-1 infection in Japanese. To confirm the association of A3H and HIV-1 infection in another ethnic group, a total of 241 HIV-1-infected Indian individuals and ethnic-matched 286 healthy controls were analyzed for the A3H polymorphisms. The frequency of 15del allele was high in the HIV-1-infected subjects as compared with the controls (0.477 vs 0.402, odds ratio (OR)=1.36, P=0.014). Haplotype analysis showed that the frequencies of 15del-105R was high (0.475 vs 0.400, OR=1.36, permutation P=0.037) in the HIV-1-infected subjects, confirming the association of A3H polymorphisms with the susceptibility to HIV-1 infection.