Dietary Supplements Containing Oat Beta-Glucan and/or Green Coffee (Poly)phenols Showed Limited Effect in Modulating Cardiometabolic Risk Biomarkers in Overweight/Obese Patients without a Lifestyle Intervention

• Published in: Nutrients Vol. 15; no. 9; p. 2223
• Main Authors: García-Cordero, Joaquín, Mateos, Raquel, González-Rámila, Susana, Seguido, Miguel A., Sierra-Cinos, José Luis, Sarriá, Beatriz, Bravo, Laura
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 08.05.2023; MDPI
• Subjects: adipokines; alanine transaminase; aspartate transaminase; beta-glucans; Biological markers; Biomarkers; blood; body composition; Carbohydrates; Cholesterol; Clinical trials; Coffee; Dextrose; Diabetes; diastolic blood pressure; Dietary supplements; Enzymes; Exercise; Fatty acids; Functional foods & nutraceuticals; Glucose; Glycosylated hemoglobin; hemoglobin; High density lipoprotein; homeostasis; Hypertension; insulin; Insulin resistance; lifestyle; Lipids; low density lipoprotein; Low density lipoproteins; Metabolism; Microbiota; oats; Obesity; Overweight; pandemic; Peptides; physical activity; Polyphenols; Prebiotics; risk; Type 2 diabetes; very low density lipoprotein; Weight control; Europe; glucose homeostasis; oat beta-glucan; green coffee hydroxycinnamates; obesity; lipid metabolism
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu15092223

Obesity has reached pandemic proportions and has become a major health concern worldwide. Therefore, it is necessary to find new strategies against this condition and its associated comorbidities. Green coffee polyphenols (GCP) and oat beta-glucans (BGs) have proven their hypolipidaemic and hypoglycaemic effects. This study aimed to examine the effects of the long-term consumption of supplements containing GCP, BG or the novel GCP/BG combination on lipid and glucose metabolism biomarkers in overweight/obese subjects who maintained their dietary habits and physical activity, hence addressing the difficulty that this population faces in adapting to lifestyle changes. A randomised, crossover, blind trial was carried out in 29 volunteers who consumed either GCP (300 mg), BG (2.5 g) or GCP/BG (300 mg + 2.5 g) twice a day for 8 weeks. Blood samples were collected, and blood pressure and body composition were measured at the beginning and end of each intervention. Total cholesterol, triglycerides, high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), very low-density lipoprotein (VLDL-C) cholesterol, glycated haemoglobin, fasting glucose, insulin, aspartate transaminase, alanine transaminase and different hormones and adipokines were analysed. Only VLDL-C (p = 0.01) and diastolic blood pressure (p = 0.027) decreased after the intervention, especially with the BG supplement. There were no other significant changes in the analysed biomarkers. In conclusion, the regular intake of GCP, BG and GCP/BG without lifestyle changes is not an efficient strategy to improve lipid and glucose homeostasis in overweight/obese subjects.