Synthesis of gemifloxacin conjugated silver nanoparticles, their amplified bacterial efficacy against human pathogen and their morphological study via TEM analysis

• Published in: Artificial cells, nanomedicine, and biotechnology Vol. 49; no. 1; pp. 661 - 671
• Main Authors: Ahmad, Touqeer, Mahbood, Fazal, Sarwar, Rizwana, Iqbal, Ayesha, Khan, Majid, Muhammad, Sayyar, AL-Riyami, Khamis, Hussain, Nusrat, Uddin, Jalal, Khan, Ajmal, Al-Harrasi, Ahmed
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.01.2021; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: Amplification; Anti-Bacterial Agents - chemistry; antibiofilm; Antiinfectives and antibacterials; Bioaccumulation; Cell membranes; Cell morphology; Controlled release; Cytotoxicity; Drug delivery; Drug resistance; Fourier analysis; Fourier transforms; Gemifloxacin; Gentian violet; Humans; Infrared analysis; Infrared spectroscopy; Metal Nanoparticles - chemistry; Metal surfaces; Methicillin; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Morphology; Nanoparticles; Pathogens; Plant Extracts - chemistry; plasmon resonance; Proteus mirabilis; Silver; Silver - chemistry; Silver - pharmacology; silver nanoparticles; Spectroscopy, Fourier Transform Infrared; Staphylococcus aureus; Staphylococcus infections; TEM; Transmission electron microscopy; Urease; Gemifloxacin; plasmon resonance; silver nanoparticles; antibiofilm; TEM

Drug-loaded nanoparticles (NPs) allow specific accumulation and controlled release of drugs to infected tissues with minimal cytotoxicity. In this study, gemifloxacin conjugated silver nanoparticles (Gemi-AgNPs) were synthesized, and the amplification of their antibacterial potential against the hum...