Conjugation of curcumin onto hyaluronic acid enhances its aqueous solubility and stability
We tried a simple method for the direct conjugation of curcumin to hyaluronic acid by utilizing reactive functional groups in hyaluronic acid such as carboxylic acid. Hyaluronic acid–curcumin conjugates form nano sized micelle in aqueous solution through hydrophobic interactions which enhances poor...
Saved in:
Published in | Journal of colloid and interface science Vol. 359; no. 1; pp. 318 - 325 |
---|---|
Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Amsterdam
Elsevier Inc
01.07.2011
Elsevier |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | We tried a simple method for the direct conjugation of curcumin to hyaluronic acid by utilizing reactive functional groups in hyaluronic acid such as carboxylic acid. Hyaluronic acid–curcumin conjugates form nano sized micelle in aqueous solution through hydrophobic interactions which enhances poor aqueous solubility and stability of curcumin. [Display omitted]
► Polymer-drug conjugates have gained much attention largely to circumvent lower drug solubility and to enhance drug stability. ► Curcumin is widely known for its medicinal properties including its anticancer efficacy. One of the serious drawbacks of curcumin is its poor water solubility which leads to reduced bioavailability. ► We synthesized Hyaluronic acid–curcumin (HA–Cur) conjugate. ► The conjugates, interestingly found to assembles as micelles in aqueous phase. ► The formation of micelles seems to improve the stability of the drug in physiological pH.
Polymer-drug conjugates have gained much attention largely to circumvent lower drug solubility and to enhance drug stability. Curcumin is widely known for its medicinal properties including its anticancer efficacy. One of the serious drawbacks of curcumin is its poor water solubility which leads to reduced bioavailability. With a view to address these issues, we synthesized hyaluronic acid–curcumin (HA–Cur) conjugate. The drug conjugate was characterized using FT-IR, NMR, Dynamic light scattering and TEM techniques. The conjugates, interestingly found to assembles as micelles in aqueous phase. The formation of micelles seems to improve the stability of the drug in phisiological pH. We also assessed cytotoxicty of the conjugate using L929 fibroblast cells and quantified by MTT assay. |
---|---|
Bibliography: | http://dx.doi.org/10.1016/j.jcis.2011.03.071 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
ISSN: | 0021-9797 1095-7103 |
DOI: | 10.1016/j.jcis.2011.03.071 |