Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend or foe?

Highlights • Chronic stress triggers loss of dopaminergic neurons within the substantia nigra. • Increased level of oxidative stress. • Suppressed glia neuroprotective functions. • Enhanced the aggregation of α-synuclein.

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Bibliographic Details
Published inBrain, behavior, and immunity Vol. 60; pp. 117 - 125
Main Authors Kooi Ong, Lin, Zhao, Zidan, Kluge, Murielle, TeBay, Clifford, Zalewska, Katarzyna, Dickson, Phillip W, Johnson, Sarah J, Nilsson, Michael, Walker, Frederick R
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.02.2017
Subjects
Allergy and Immunology
alpha-Synuclein - metabolism
Animals
Astrocytes
Astrocytes - metabolism
Chronic stress
Dopaminergic Neurons - metabolism
Male
Mice, Inbred C57BL
Microglia
Microglia - metabolism
Neurodegeneration
Neuroglia - metabolism
Oxidative stress
Oxidative Stress - physiology
Psychiatry
Stress, Physiological - physiology
Substantia nigra
Substantia Nigra - metabolism
α-Synuclein
substantia nigra
neurodegeneration
astrocytes
chronic stress
microglia
α-synuclein
oxidative stress
α-Synuclein
Oxidative stress
Chronic stress
Astrocytes
Neurodegeneration
Substantia nigra
Microglia
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Summary:Highlights • Chronic stress triggers loss of dopaminergic neurons within the substantia nigra. • Increased level of oxidative stress. • Suppressed glia neuroprotective functions. • Enhanced the aggregation of α-synuclein.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2016.10.001