Recent progress in the study of methylated tumor suppressor genes in gastric cancer

Gastric cancer is one of the most common malignancies and a leading cause of cancer mortality worldwide. The pathogenesis mechanisms of gastric cancer are still not fully clear. Inactivation of tumor suppressor genes and activation of oncogenes caused by genetic and epigenetic alterations are known...

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Bibliographic Details
Published inAi zheng Vol. 32; no. 1; pp. 31 - 41
Main Authors Hu, Xiao-Tong, He, Chao
Format Journal Article
LanguageEnglish
Published England Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province%Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province 01.01.2013
Department of Colorectal Surgery, Sir Run Run Shaw Hospital, Hangzhou, Zhejiang 310016, P.R.China
Sun Yat-sen University Cancer Center
Subjects
Apoptosis
Cell Adhesion
Cell Cycle
CpG Islands - genetics
DNA Methylation
DNA Repair
Epigenesis, Genetic
Genes, Tumor Suppressor
Helicobacter Infections - genetics
Helicobacter pylori
Humans
Neoplasm Invasiveness
Promoter Regions, Genetic - genetics
Review
Stomach Neoplasms - genetics
Stomach Neoplasms - metabolism
Stomach Neoplasms - microbiology
Stomach Neoplasms - pathology
Tumor Suppressor Proteins - genetics
Tumor Suppressor Proteins - metabolism
发病机制
恶性肿瘤
抑癌基因
甲基化
癌组织
肿瘤抑制基因
胃癌
表观遗传
tumor suppressor genes
Gastric cancer
methylation
epigenetics
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Summary:Gastric cancer is one of the most common malignancies and a leading cause of cancer mortality worldwide. The pathogenesis mechanisms of gastric cancer are still not fully clear. Inactivation of tumor suppressor genes and activation of oncogenes caused by genetic and epigenetic alterations are known to play significant roles in carcinogenesis. Accumulating evidence has shown that epigenetic silencing of the tumor suppressor genes, particularly caused by hypermethylation of CpG islands in promoters, is critical to carcinogenesis and metastasis. Here, we review the recent progress in the study of methylations of tumor suppressor genes involved in the pathogenesis of gastric cancer. We also briefly describe the mechanisms that induce tumor suppressor gene methylation and the status of translating these molecular mechanisms into clinical applications.
Bibliography:Gastric cancer is one of the most common malignancies and a leading cause of cancer mortality worldwide. The pathogenesis mechanisms of gastric cancer are still not fully clear. Inactivation of tumor suppressor genes and activation of oncogenes caused by genetic and epigenetic alterations are known to play significant roles in carcinogenesis. Accumulating evidence has shown that epigenetic silencing of the tumor suppressor genes, particularly caused by hypermethylation of CpG islands in promoters, is critical to carcinogenesis and metastasis. Here, we review the recent progress in the study of methylations of tumor suppressor genes involved in the pathogenesis of gastric cancer. We also briefly describe the mechanisms that induce tumor suppressor gene methylation and the status of translating these molecular mechanisms into clinical applications.
Xiao-Tong Hu and Chao He（1Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, 2Department of Colorectal Surgery, Sir Run Run Shaw Hospital, Hangzhou, Zhe iang 310016, P. R. China.）
44-1195/R
Gastric cancer, methylation, tumor suppressor genes, epigenetics
ISSN:1000-467X
1944-446X
DOI:10.5732/cjc.011.10175