Photoactive electrospun fibers for inducing cell death

A photoactive electrospun material producing reactive oxygen species (ROS) upon light irradiation is reported. The phototoxicity of the generated ROS is spatially restricted to the fiber-tissue interface by conjugation of the photosensitizer to a macromolecule. Photo-triggered ROS is produced on dem...

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Bibliographic Details
Published inAdvanced healthcare materials Vol. 3; no. 4; p. 494
Main Authors Gabriel, Doris, Cohen-Karni, Tzahi, Huang, David, Chiang, Homer H, Kohane, Daniel S
Format Journal Article
LanguageEnglish
Published Germany 01.04.2014
Subjects
Animals
Cell Death - drug effects
Cell Line
Electrochemical Techniques - instrumentation
Electrochemical Techniques - methods
Mice
NIH 3T3 Cells
Photochemical Processes
Polyesters - pharmacology
Polylysine - pharmacology
Spectrometry, Fluorescence
biomedical devices
spatiotemporal cell death modulation
pheophorbide a
photo-triggered materials
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Summary:A photoactive electrospun material producing reactive oxygen species (ROS) upon light irradiation is reported. The phototoxicity of the generated ROS is spatially restricted to the fiber-tissue interface by conjugation of the photosensitizer to a macromolecule. Photo-triggered ROS is produced on demand and repeatedly. It induces death of mammalian cells growing on the material surface with high spatial resolution.
ISSN:2192-2659
DOI:10.1002/adhm.201300318