Duloxetine‐induced syndrome of inappropriate antidiuretic hormone secretion in a patient with neuropathic pain

Key Clinical Message Syndrome of inappropriate antidiuretic hormone secretion (SIADH) induces hyponatremia accompanied by uric acid reduction. We report a case of a patient with small‐cell lung cancer who developed SIADH with hypouricemia after duloxetine treatment and discuss the potential underlyi...

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Published inClinical case reports Vol. 12; no. 11; pp. e9526 - n/a
Main Authors Takahashi, Nobuyuki, Mori, Yukiko, Momo, Kenji, Murakami, Hidetomo, Tanaka, Hironori
Format Journal Article
LanguageEnglish
Published England John Wiley & Sons, Inc 01.11.2024
John Wiley and Sons Inc
Wiley
Subjects
Case Report
Drug dosages
duloxetine
General Medicine
Hyponatremia
Immunoglobulins
Lung cancer
Medical prognosis
neuropathic pain
Pain
Patients
Pharmacology and Pharmacy
Plasma
small‐cell lung cancer
Sodium
syndrome of inappropriate antidiuretic hormone secretion
Uric acid
syndrome of inappropriate antidiuretic hormone secretion
duloxetine
neuropathic pain
small‐cell lung cancer
uric acid
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Summary:Key Clinical Message Syndrome of inappropriate antidiuretic hormone secretion (SIADH) induces hyponatremia accompanied by uric acid reduction. We report a case of a patient with small‐cell lung cancer who developed SIADH with hypouricemia after duloxetine treatment and discuss the potential underlying mechanisms. SIADH and hypouricemia improved after duloxetine was switched to mirogabalin.
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ISSN:2050-0904
2050-0904
DOI:10.1002/ccr3.9526