Contractions to 5‐hydroxytryptamine in human coronary artery and human saphenous vein

Isometric contractions were obtained to 5‐hydroxytryptamine receptor agonists in human saphenous vein and human coronary artery. Based on the interaction with the 5‐HT2 receptor antagonist ketanserin, both 5‐ HT1 and 5‐HT2 receptors are involved in contractions of human saphenous vein, but the predo...

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Bibliographic Details
Published inBritish journal of clinical pharmacology Vol. 30; no. S1; pp. 107S - 108S
Main Authors Borton, M., Neligan, M., Wood, F., Dervan, P., Goggins, K., Docherty, J.R.
Format Journal Article Conference Proceeding
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.01.1990
Blackwell Science
Subjects
Biological and medical sciences
Blood vessels and receptors
Coronary Vessels - drug effects
Free Communications
Fundamental and applied biological sciences. Psychology
Humans
In Vitro Techniques
Isometric Contraction
Muscle Contraction - drug effects
Muscle, Smooth, Vascular - drug effects
Receptors, Serotonin - drug effects
Receptors, Serotonin - physiology
Saphenous Vein - drug effects
Serotonin - pharmacology
Serotonin Antagonists - pharmacology
Vertebrates: cardiovascular system
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Summary:Isometric contractions were obtained to 5‐hydroxytryptamine receptor agonists in human saphenous vein and human coronary artery. Based on the interaction with the 5‐HT2 receptor antagonist ketanserin, both 5‐ HT1 and 5‐HT2 receptors are involved in contractions of human saphenous vein, but the predominant subtype involved in contractions of human coronary artery is the 5‐HT1 receptor.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0306-5251
1365-2125
DOI:10.1111/j.1365-2125.1990.tb05476.x