Evidence that the positive inotropic effects of the alkylxanthines are not due to adenosine receptor blockade
1 We investigated the possibility that the positive inotropic effects of the alkylxanthines are due to adenosine receptor blockade. 2 The potency of 8‐phenyltheophylline, theophylline and enprofylline as adenosine antagonists was assessed in vitro, using the guinea‐pig isolated atrium, and in vivo,...
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Published in | British journal of pharmacology Vol. 81; no. 2; pp. 401 - 407 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.02.1984
Nature Publishing Nature Publishing Group |
Subjects | |
Online Access | Get full text |
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Summary: | 1
We investigated the possibility that the positive inotropic effects of the alkylxanthines are due to adenosine receptor blockade.
2
The potency of 8‐phenyltheophylline, theophylline and enprofylline as adenosine antagonists was assessed in vitro, using the guinea‐pig isolated atrium, and in vivo, using the anaesthetized dog.
3
The order of potency of the alkylxanthines as antagonists of the negative inotropic response to 2‐chloroadenosine in vitro, and of the hypotensive response to adenosine in vivo was 8‐phenyltheophylline > theophylline > enprofylline.
4
The order of potency of the alkylxanthines as positive inotropic and chronotropic agents in the anaesthetized dog was enprofylline > theophylline > 8‐phenyltheophylline.
5
The results of this study indicate that the inotropic effects of the alkylxanthines in the anaesthetized dog are not due to adenosine receptor blockade. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0007-1188 1476-5381 |
DOI: | 10.1111/j.1476-5381.1984.tb10092.x |