Abies koreana Essential Oil Inhibits Drug-Resistant Skin Pathogen Growth and LPS-Induced Inflammatory Effects of Murine Macrophage

• Published in: Lipids Vol. 44; no. 5; pp. 471 - 476
• Main Authors: Yoon, Weon-Jong, Kim, Sang-Suk, Oh, Tae-Heon, Lee, Nam Ho, Hyun, Chang-Gu
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 01.05.2009; Springer-Verlag; Springer‐Verlag; Springer Nature B.V
• Subjects: Abies - chemistry; Abies koreana; acne; Acne vulgaris; Acne Vulgaris - microbiology; Animals; Anti-Bacterial Agents - pharmacology; anti-inflammatory activity; Anti-Inflammatory Agents - pharmacology; antibacterial properties; Bacterial diseases; bacterial infections; Biomarkers; Biomedical and Life Sciences; Cell Line; Communication; cultured cells; Drug Resistance; Essential oil; Essential oils; Inflammation; Inflammation - chemically induced; Inflammation - drug therapy; interleukin-1; interleukin-6; Life Sciences; Lipidology; Lipopolysaccharides - pharmacology; macrophages; Macrophages - drug effects; Macrophages - microbiology; Medical Biochemistry; Medicinal Chemistry; medicinal properties; Mice; Microbial Genetics and Genomics; Microbial Sensitivity Tests; Neurochemistry; nitric oxide; Nutrition; Oils, Volatile - pharmacology; Pathogens; Propionibacterium acnes; Propionibacterium acnes - drug effects; prostaglandins; Skin pathogen; Staphylococcus epidermidis; Staphylococcus epidermidis - drug effects; tumor necrosis factor-alpha; Acne vulgaris; Essential oil; Inflammation; Skin pathogen
• ISSN: 0024-4201; 1558-9307
• DOI: 10.1007/s11745-009-3297-3

Since acne vulgaris is the combined result of a bacterial infection and the inflammatory response to that infection, we examined whether Abies koreana essential oil (AKE) possessed anti-inflammatory and antibacterial activities against skin pathogens. In this study, AKE showed excellent antibacterial activities against drug-susceptible and -resistant Propionibacterium acnes and Staphylococcus epidermidis, which are acne-causing bacteria. In addition, AKE reduced the LPS-induced secretion of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, NO and PGE₂ in RAW 264.7 cells, indicating that it has anti-inflammatory effects. Therefore, we suggest that AKE may be an attractive candidate for promoting skin health.