The ratio of circulating follicular T helper cell to follicular T regulatory cell is correlated with disease activity in systemic lupus erythematosus

Follicular T regulatory (Tfr) cells inhibit follicular T helper (Tfh) cells mediated B cell responses. Tfh cells are involved in the pathogenesis of systemic lupus erythematosus (SLE). However, the role of Tfr cells in SLE remains unclear. The frequency of circulating Tfr and Tfh cells were examined...

Full description

Saved in:
Bibliographic Details
Published inClinical immunology (Orlando, Fla.) Vol. 183; pp. 46 - 53
Main Authors Xu, Bihua, Wang, Shuang, Zhou, Mianjing, Huang, Yuefang, Fu, Rong, Guo, Chaohuan, Chen, Jingxian, Zhao, Jijun, Gaskin, Felicia, Fu, Shu Man, Yang, Niansheng
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.10.2017
Subjects
Online AccessGet full text

Cover

Loading…
More Information
Summary:Follicular T regulatory (Tfr) cells inhibit follicular T helper (Tfh) cells mediated B cell responses. Tfh cells are involved in the pathogenesis of systemic lupus erythematosus (SLE). However, the role of Tfr cells in SLE remains unclear. The frequency of circulating Tfr and Tfh cells were examined in SLE patients and healthy controls. The frequency of circulating Tfr cell decreased and Tfh/Tfr ratio increased in SLE patients. Serum anti-dsDNA antibody level positively correlated with frequency of Tfh cells and Tfh/Tfr ratios but negatively correlated with the frequency of Tfr cells. Moreover, the frequency of Tfr and Tfh/Tfr ratio but not that of Tfh was correlated with diseases activity. In addition, increase in Tfr cell numbers and decrease in the Tfh/Tfr ratios were observed with successful treatments. Thus, Tfr cells should be considered as a biomarker for SLE and their role in the pathogenesis of SLE warrants further investigation. •The frequency of circulating Tfr cells decreased and Tfh/Tfr ratio increased in SLE patients.•Increased active subpopulation was found in Tfh and Tfr cells of SLE.•The frequency of Tfr and Tfh/Tfr ratio but not that of Tfh was correlated with diseases activity.•Increase in Tfr cell numbers and decrease in the Tfh/Tfr ratios were observed with successful treatments.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
These authors contributed equally to this work.
ISSN:1521-6616
1521-7035
1521-7035
DOI:10.1016/j.clim.2017.07.004