Pattern recognition receptors in zebrafish provide functional and evolutionary insight into innate immune signaling pathways

• Published in: Cellular & molecular immunology Vol. 14; no. 1; pp. 80 - 89
• Main Authors: Li, Yajuan, Li, Yuelong, Cao, Xiaocong, Jin, Xiangyu, Jin, Tengchuan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.01.2017; Nature Publishing Group
• Subjects: Amino Acid Sequence; Animals; Antibodies; Base Sequence; Biological Evolution; Biomedical and Life Sciences; Biomedicine; Humans; Immunity, Innate; Immunology; Inflammasomes - metabolism; Medical Microbiology; Microbiology; Receptors, Pattern Recognition - metabolism; Review; Signal Transduction - immunology; Vaccine; Zebrafish - immunology; 信号通路; 先天免疫; 免疫防御机制; 受体; 受损细胞; 斑马鱼; 模式识别; 进化关系; NOD-like receptors; Toll-like receptors; zebrafish; caspases; RIG-I-like receptors; pattern recognition receptor; innate immune system
• ISSN: 1672-7681; 2042-0226; 2042-0226
• DOI: 10.1038/cmi.2016.50

Pattern recognition receptors （PRRs） and their signaling pathways have essential roles in recognizing various components of pathogens as well as damaged cells and triggering inflammatory responses that eliminate invading microorganisms and damaged cells. The zebrafish relies heavily on these primary defense mechanisms against pathogens. Here, we review the major PRR signaling pathways in the zebrafish innate immune system and compare these signaling pathways in zebrafish and humans to reveal their evolutionary relationship and better understand their innate immune defense mechanisms.